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4 TH WORLD BANK ACE WORKSHOP

The West African Centre for Cell Biology of Infectious Pathogens (WACCBIP) aims to improve the diagnosis, prevention, and control of infectious diseases in sub-Saharan Africa. With various programs, workshops, and scholarships, WACCBIP is making significant contributions to the field of infectious pathogens.

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4 TH WORLD BANK ACE WORKSHOP

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  1. 4TH WORLD BANK ACE WORKSHOP Sika Menka (Monitoring & Evaluation Officer) West African Centre for Cell Biology of Infectious Pathogens

  2. CENTRE TEAM • Dr. Gordon A. Awandare - Director • Prof. Kwadwo A. Koram - Deputy Director • Dr. OlukemiAmodu - Representative of regional partners • Mr. Collins Amofah - Finance Focal Person • Ms. Sika Menka - Monitoring and Evaluation Focal Person • Mrs. Constance Kocke - Procurement Focal Person

  3. MISSION OF WACCBIP • The mission of WACCIP is to: Improve diagnosis, prevention and control of infectious diseases in sub-Saharan Africa by providing advanced level training and research excellence on the cell and molecular biology of infectious pathogens.

  4. AWARDS AND ACHIEVEMENTS • WACCBIP- Wellcome Trust DELTAS Africa Initiative • The centre will receive £ 5.1 million over 5 years for human genetics training of 15 PhDs and 12 Postdoctoral fellows • Grants awarded to students • Noguchi Graduate Research Scheme – 6 MPhil students awarded • DANIDA-Malaria Vaccine Research and Capacity building in Ghana – full scholarships for 4 PhD Students • 2 Royal Society/Leverhulme Grants – scholarships for 2 PhD students • AIMS – scholarship for 1 PhD student • Building Strong Universities (BSU) II project - scholarships for 2 PhD students

  5. Program Activities and their Disbursement Linked Indicators • DLI 2.1- Short courses launched • 1st Workshop on Molecular Biology, Pathogenesis and Diagnostics of Neglected diseases (July, 2014)

  6. Program Activities and their Disbursement Linked Indicators • DLI 2.1- Short courses launched • 2nd Workshop on Molecular Biology, Pathogenesis and Diagnostics of Neglected diseases (July, 2015)

  7. Program Activities and their Disbursement Linked Indicators • Short courses planned for next year • WACCBIP-American Society of Cell Biology workshop (January 18 - 29, 2016) • 3rd Workshop on Molecular Biology, Pathogenesis and Diagnostics of Neglected diseases (July 4 -15, 2016)

  8. Program Activities and their Disbursement Linked Indicators • DLI 2.2- New Masters programme 1st Cohort: 30 students (7 female, 23 male, 4 regional) • MSc Biochemistry - 6 students • MPhil Biochemistry- 2 student • MPhil Molecular Biology – 2 students • MPhil Molecular Cell Biology of Infectious Diseases (MCBI) - 20 students

  9. Program Activities and their Disbursement Linked Indicators • DLI 2.2- New Masters programme 2nd Cohort, 22 students (9 female, 13 male, 0 regional) • MSc Biochemistry – 1 student • MPhil Biochemistry - 2 students • MPhil Molecular Biology - 3 students • MPhil Molecular Cell Biology of Infectious Diseases (MCBI) - 16 students

  10. Program Activities and their Disbursement Linked Indicators • DLI 2.3- New PhD Programmme • PhD Biochemistry • PhD Molecular Cell Biology of Infectious Diseases (MCBI) -1st cohort: 15 students; 7 females, 8 males, 0 regional - 2nd cohorts:13 students; 5 females, 8 males, 2 regional

  11. Program Activities and their Disbursement Linked Indicators • DLI 2.4 - Outreach Periods/ Internships Faculty internships – 5 (1 female, 4 male, 1 regional) Cambridge CAPREx Programme WACCBIP Student internship - 6 (6 female, 0 male, 0 regional) London School of Hygiene and Tropical Medicine, UK University of Cambridge, UK Novartis, Switzerland University of Copenhagen, UK Pasteur Institute, France

  12. Program Activities and their Disbursement Linked Indicators • DLI 2.5- Accreditation • National Accreditation • New programmes (MPhil MCBI and PhD MCBI) assessed and accredited by National Accreditation Board • International reviews and Accreditation • The ITC of ASCB reviewed and advised on all new curricula • Visit by the Society of Biology, UK later this year subject to availability of funds

  13. Program Activities and their Disbursement Linked Indicators • DLI 2.6- Published Articles • 38 internationally recognized publications accrued between March, 2014 - August, 2015 by WACCBIP faculty • 4 publications co-authored with regional partners.

  14. Program Activities and their Disbursement Linked Indicators • Publications co-authored with regional partners. • Narh, C. A., Mosi, L., Quaye, C., Dassi, C., Konan, D. O., Tay, S. C. K., de Souza, D. K., Boakye, D. A., & Bonfoh, B. (2015). Source Tracking Mycobacterium ulcerans Infections in the Ashanti Region, Ghana. PLoS Neglected Tropical Diseases, 9(1):18 • Bowyer, P. W., Stewart, L. B., Aspeling-Jones, H., Mensah-Brown, H. E., Ahouidi, A. D., Amambua-Ngwa, A., Awandare, G. A., & Conway, D. J. (2015). Variation in Plasmodium falciparum Erythrocyte Invasion Phenotypes and Merozoite Ligand Gene Expression across Different Populations in Areas of Malaria Endemicity. Infection and Immunity, 83(6):2575-82 • Narh, C. A., Mosi, L., Quaye, C., Tay, S. C. K., Bonfoh, B., & de Souza, D. K. (2014). Genotyping tools for Mycobacterium ulcerans- drawbacks and future prospect. Mycobacterial Diseases, 4(2) • Ghansah, A., Amenga-Etego, L., Amambua-Ngwa, A., et al. (2014). Monitoring parasite diversity for malaria elimination in sub-Saharan Africa. Science, 345(6202), 1297-1298

  15. Program Activities and their Disbursement Linked Indicators • Internationally recognized publications by WACCBIP faculty • Asante-Poku, A., Otchere, I.D., Danso, E., Mensah, D.D., Bonsu, F., Gagneux, S., & Yeboah-Manu, D. (2015). Evaluation of GenoTypeW MTBDR plus for the rapid detection of drug-resistant tuberculosis in Ghana. International Journal of Tuberculosis and Lung Disease. 19(8):954-959 • Tsouh, P. V. F., Addo, P., Yeboah-Manu, D., & Boyom, F. F. (2015). Methods used in preclinical assessment of anti-Buruli ulcer agents: A global perspective. Journal of Pharmacological and Toxicological Methods. 73:27-33 • Nguta, J. M., Appiah-Opong, R., Nyarko, A. K., Yeboah-Manu, D., Addo, P. G. A. (2015). Medicinal plants used to treat TB in Ghana. International Journal of Mycobacteriology. 4(2):116-123 • Badu, K., Gyan, B., Appawu, M., Mensah, D., Dodoo, D., Yan, G., Drakeley, C., Zhou, G., Owusu-Dabo, E., & Koram, K. A. (2015). Serological evidence of vector and parasite exposure in Southern Ghana: The dynamics of malaria transmission intensity. Parasites and Vectors. 8(1), 861

  16. Program Activities and their Disbursement Linked Indicators • Duffy, C. W., Assefa, S. A., MacInnis, B., Abugri, J., Amoako, N., Owusu-Agyei, S., Anyorigiya, T., Kwiatkowski, D. P., Conway, D. J. & Awandare, G. A. (2015). Comparison of genomic signatures of selection on Plasmodium falciparum between different regions of a country with high malaria endemicity. BMC Genomics, 16:527 • Adjimani, J. P. & Asare, P. (2015). Antioxidant and free radical scavenging activity of iron chelators. Toxicology reports, 721-728 • Anum, D., Kusi, K. A., Ofori, M. F., Koram, K. A.,, Dodoo, D., et al. (2015). Measuring naturally acquired ex vivo IFN-γ responses to Plasmodium falciparum Cell-traversal protein for ookinetes and sporozoites (CelTOS) in Ghanaian adults. Malaria Journal, 14(20) • Hori, T., Koram, K., Nyarko, A., Okine L., Edoh, D., et al. (2015). Procyanidin trimer C1 derived from Theobroma cacao reactivates latent human immunodeficiency virus type 1 provirus. Biochemical and Biophysical Research Communications, 459(2):288-93 • Mensah-Brown, H. E., Amoako, N., Abugri, J., Conway, D. J., Awandare, G. A., et al. (2015). Analysis of erythrocyte invasion mechanisms of Plasmodium falciparum clinical isolates across three endemic areas within one country. The Journal of Infectious Diseases, pii: jiv207.

  17. Program Activities and their Disbursement Linked Indicators • Stoler, J., Delimini, R. K., Bonney, K. J.H., Oduro, A. R., Owusu-Agyei, S., Fobil, J. N., & Awandare, G. A. (2015). Evidence of recent Dengue exposure among malaria parasite-positive children in three urban centers in Ghana. The American Journal of Tropical Medicine and Hygiene, 92(3), 497-500 • Asante-Poku, A., Yeboah-Manu, D., Otchere, I. D., et al. (2015). Mycobacterium africanum is associated with patient ethnicity in Ghana. PLoS Neglected Tropical Disease, 9(1):e3370 • Ocloo, A., Appiah‐Opong, R, Chama, M. A., et al. (2015). An In Situ Study on the Effects of Extracts of Taraxacum Officinale, Paulliniia Pinnata and Thonningia Sanguinea on Mitochondrial Function. Journal of Food Biochemistry 39(1):55-63 • Suzuki, M., Koram, K., Ohta, N., Boakye, D. A., et al. (2015). New anti-trypanosomal active tetracyclic iridoid isolated from morinda lucida benth. Bioorganic and Medicinal Chemistry Letters, 25(15), 3030-3033. doi:10.1016/j.bmcl.2015.05.003 • Asiedu-Larbi, J., Adjimani, J. P., Okine, L. K. N., Addy, M. E., et al. (2014). Efficacy studies on Mist Diodia, a herbal preparation for the management of hypertension in rodents. Medicinal & Aromatic Plant Research Journal, 2(1), 6-17.

  18. Program Activities and their Disbursement Linked Indicators • Amoako, N., Asante, K. P., Adjei, G., Awandare, G. A., et al. (2014). Associations between Red Cell Polymorphisms and Plasmodium falciparum Infection in the Middle Belt of Ghana. PLoS One, 9(12) • Bratschi, M. W., Bolz, M., Yeboah-Manu, D., Ruf, M. T., Pluschke, G. et al. (2014). Primary cultivation: factors affecting contamination and Mycobacterium ulcerans growth after long turnover time of clinical specimens. BMC Infectious Diseases,14(1):636 • Abuaku, B., Quaye, L., Duah, N., Quashie, N., & Koram, K. (2014). Managing antimalarial drug resistance in Ghana: The importance of surveillance, Towards Effective Disease Control in Ghana: Research and policy implications (Clinical Science series No. 5-1). Sub-Saharan publishers. ISBN: 978-9988-647-50-6 • Adu, B., Jepsen, M. P., Gerds, T. A., Kyei-Baafour, E., Christiansen, M., Dodoo, D., & Theisen, M. (2014). Fc gamma receptor 3B (FCGR3B-c.233C>A-rs5030738) polymorphism modifies the protective effect of malaria specific antibodies in Ghanaian children. The Journal of Infectious Diseases, 209(2), 285-9 • Ampomah, P., Stevenson, L., Ofori, M. F., et al. (2014). Kinetics of B Cell Responses to Plasmodium falciparum Erythrocyte Membrane Protein 1 in Ghanaian Women Naturally Exposed to Malaria Parasites. The Journal of Immunology, 192(11), 5236-44

  19. Program Activities and their Disbursement Linked Indicators • Asante-Poku, A., Aning, K. G., Boi-Kikimoto, B., & Yeboah- Manu, D., (2014). Prevalence of bovine tuberculosis in a dairy cattle farm and a research farm in Ghana, Onderstepoort Journal of Veterinary Research, 81(2): 716-21 • Asante-Poku, M., Nyaho, S., Borrell, S., Comas, I., Gagneux, S., & Yeboah-Manu, D. (2014). Evaluation of customised lineage-specific sets of MIRU-VNTR loci for genotyping Mycobacterium tuberculosis complex isolates in Ghana. PloS One, 9(3), e92675. • Asare, K. K., Boampong, J. N., Afoakwah, R., Ameyaw, E. O., Sehgal, R., & Quashie, N. B. (2014). Use of Proscribed Chloroquine is associated with an increased risk of Pfcrt T76 mutation in some parts of Ghana. Malaria Journal, 13(246). • Asare, K. K., Boampong, J. N., Ameyaw, E. O., Thomford, A. K., Afoakwah, R., Kwakye-Nuako, G., Thomford, K. P., & Quashie, N. B. (2014). Microscopic identification of possible Clonorchiasis/ Opisthorchiasis Infection in Two Ghanaian Women with an Undiagnosed Abdominal Discomfort: Two Case Report. Journal of Medical Case Reports, 8(369). • Awodele, O., Tomoye, O. P., Quashie, N. B., et al. (2014). Gentamicin Nephrotoxicity: Animal Experimental Correlate with Human Pharmacovigilance Outcome. Biomedical Journal, doi: 10.4103/2319-4170.131387.

  20. Program Activities and their Disbursement Linked Indicators • Donkor, K., Antwi, S., Asiedu-Larbi, J., Takyi, N., & Okine, L. K. (2014). Sub-chronic toxicity studies of Asena, a poly-herbal formulation for the treatment of arthritis in rat. Medicinal and Aromatic Plants Research Journal, 2(1), 18-27. • Greenwood, B., & Koram, K. A. (2014). Malaria control in Africa: progress but still much to do. Lancet, 383(9930), 1703-4. • Kusi, K. A., Bosomprah, S., Dodoo, D., Kyei-Baafour, E., Dickson, E. K., Mensah, D., Angov, E., Dutta, S., Sedegah, M., & Koram, K. A. (2014). Anti-sporozoite antibodies as alternative markers for malaria transmission intensity estimation. Malaria journal, 13(1), 103. • Ocloo, A., Okpattah, W. E., Quasie, O., Sakyiamah, M. M., & Okine, L. K. N. (2014). Concurrent administration of aqueous Extract of Cryptolepis sanguinolenta reduces the effectiveness of Artesunate against Plasmodium berghei in Rats. Journal of Applied Pharmaceutical Science, 4(3), 024-028. • Williamson, H. R., Aqqad, M., Donnell, R., Mosi, L., Merritt, R. W., & Small, P. L. C. (2014). Laboratory Studies on the ability of Mycobacterium ulcerans to infect through open wounds. PLoS Neglected Tropical Disease, 8(4), e2770

  21. Program Activities and their Disbursement Linked Indicators • Röltgen, K., Bratschi, M. W., Ross, A., Aboagye, S. Y., Ampah, K. A., Bolz, M., Andreoli, A., Pritchard, J., Minyem, J. C., Noumen, D., Koka, E., Um Boock, A., Yeboah-Manu, D., & Pluschke, G. (2014). Late onset of the serological response against the 18 kDa small heat shock protein of Mycobacterium ulcerans in children. PLoS Neglected Tropical Disease, 8(5), e2904 • Sanuade, O. A., Anarfi, J. K., Aikins, Ad., & Koram, K. A. (2014). Patterns of cardiovascular disease mortality in Ghana: a 5-year review of autopsy cases at Korle-Bu Teaching Hospital. Ethnicity and Diseases, Winter, 24(1), 55-9 • Stoler, J., al Dashti, R. A., Anto, F., Fobil, J. N., & Awandare, G. A. (2014). Deconstructing "malaria": West Africa as the next front for dengue fever surveillance and control. Acta Tropica, 134(1), 58 - 65 • Tettey, C. O., Ocloo, A., Nagajyothi, P. C. N., & Lee, K. D. (2014). Anti-proliferative and Anti-microbial Activities of Taraxacum officinale (Dandelion) Leaf Extracts. Journal of Applied Pharmaceutical Science, 4(3), 041-045 • Tettey, C. O., Ocloo, A., Nagajyothi, P. C. N., & Lee, K. D. (2014). Antioxidant activity, of solvent-fractionated Taraxacum officinale (dandelion) Leaves. Journal of Herbs, Spices and Medicinal Plants, 20(4), 329-340

  22. Program Activities and their Disbursement Linked Indicators • DLI 2.7- Revenue Generated • The centre has been contracted to provide educational services in the areas of health to The Gambia Republic under the World Bank ACE Project • Under this arrangement, the centre is expected to will generate a total $ 214,00.00 for the training of: - 2 PhDs= $ 146,000.00 - 2 Masters= $ 68,000.00 • WACCBIP- Wellcome Trust DELTAS Africa Initiative • The centre will receive £ 5.1 million over 5 years for human genetics training of 15 PhDs and 12 Postdoctoral fellows • First disbursement of $934,098 received

  23. Program Activities and their Disbursement Linked Indicators • DLI 2.8 - Milestones for Education & Research Environment • Begin construction of the new building including graduate lecture rooms, seminar room, bioinformatics lab • 60% completion of the building facility completed • Establishment of research core facility • 100% completion of the building facility

  24. Program Activities and their Disbursement Linked Indicators • Milestone Progress • Establishment of research core facility - Opened tender and procured a flow cytometer. Awaiting delivery and installation of equipment • Begin construction of the new building including graduate lecture rooms, seminar room, bioinformatics lab - Requested tender opening for selecting a contractor for the building

  25. First Disbursement Expenditure First Disbursement: $728,838.20

  26. Program Challenges • Top 3 challenges to program include: • Recruitment of foreign/regional students • Industry partnership development • Challenges associated with importing laboratory supplies and consumables for research

  27. Program Management Challenges • Top 2 program management/operations challenges include: • Delays in disbursement of funds • Bureaucratic procurement processes

  28. Top Goal/Hope for the next year • Generate more revenue through: -Training/teaching contracts - Laboratory supply store - Private sector engagement (consultancy and sponsorship) • Core research facility and e-learning platform should be established • Increment in regional and female student numbers • International accreditation from SoB, UK • Embark on outreach programmes

  29. Thank You

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