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Growth Hormone (GH)

Growth Hormone (GH). Holly Farris. What Is It?. 191-amino acid, single chained polypeptide Synthesized, stored, and secreted by somatotrophic cells Anterior Pituitary gland. Function. Increased height in childhood and adolescents –most known effect Increases mineralization of bones

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Growth Hormone (GH)

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  1. Growth Hormone (GH) Holly Farris

  2. What Is It? • 191-amino acid, single chained polypeptide • Synthesized, stored, and secreted by somatotrophic cells • Anterior Pituitary gland

  3. Function • Increased height in childhood and adolescents –most known effect • Increases mineralization of bones • Muscle mass • Stimulates growth of internal organs- excluding the brain • Immune system

  4. Positive or Negative? • Negative • High blood levels of IGF-I leads to decreased secretion of GH • IGF-1 directly suppresses the somatotrophic cells

  5. Hyper • Gigantism- excessive growth, usually in childhood • Most common • Pituitary Tumor - causes headaches, impair vision by pressure on the optic nerves

  6. Hypo • In children: • Growth failure • Short stature • In adults: • Increase in fat mass • Decrease muscle mass, energy and quality of life

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