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2. Lersivirine: a next-generation NNRTI with unique binding and potent activity against HIV-1. Binds to the reverse transcriptase (RT) enzyme in a novel way1Unique resistance profile2 Antiretroviral (ARV) activity2IC50 = 5.83 nM; 1.81 ng/mL (PBC)Resistance generated in vitro2V108I pathway to re
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