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Progress of the work of the COE on “Systems Biology and Bio-medical Engineering”

This report summarizes the progress of the COE on Systems Biology and Biomedical Engineering at the Technology Campus, University College of Technology, University of Calcutta. It includes the development of digital micro-fluidics chip, computer-aided diagnosis systems, optical methods for non-invasive diagnosis, and more. The COE has achieved notable achievements such as patents filed and granted, journal and conference publications, collaborations, and product development with industries. The report also discusses key issues and concerns, and the long-term plan of the COE.

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Progress of the work of the COE on “Systems Biology and Bio-medical Engineering”

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  1. Progress of the work of the COE on “Systems Biology and Bio-medical Engineering” TEQIP Phase II Grant No. :266 (Sanc)/EH/P/SPFU/WB/2013/08 Technology Campus, University College of Technology, University of Calcutta, Block-JD, Sector –III, Salt Lake City, Kolkata-700106 19th October, 2016, Progress Meeting

  2. CoE in a Nutshell Development of Digital micro-fluidics chip Computer aided diagnosis systems Faculty: 1+2 Research Scholars:3+1 Faculty: 2+1 Research Scholars:4+3 Systems Biology & Biomedical Engineering Optical methods for non-invasive diagnosis Cell systems modeling Faculty: 2+1 Research Scholars:2+1 Faculty: 2+1 Research Scholars:4+2

  3. Synergistic Progress Biomedical Engineering New Algorithms System and Process Models Systems Biology Theoretical Basis and Development of Bio-Sensors for Adulteration in Food CAD for Orthopedic Deformities/ lung nodule Prediction Design of Wireless Plethysmography Sensor Key Contributions Label free detection of thalassemia Sensor and Circuit Design for Micro-fluidic Application Construction and Analysis of Rice genome-scale metabolic network Diagnostic and Therapeutic Application for Cancer using Magnetic Hyperthermia Fluorescence amplification of the Photosynthetic system 3D Image Reconstruction of Biological Samples 3D Functional Mapping of Multi-Modal Images >90% Completed>70% CompletedInitiated

  4. SUMMARY of PROGRESS • Patent Filed: 12 • Patent Granted: 3 • Journal Pub.: 60 • Conference Pub. 40 + 15 Book Chap + 3 Books • Représentative Journal: • NAR (I. F.: 9.1); Nature Scientific reports; IEEE Transactions, IEEE ESI, Elsevier Micro. Appl. Phys. Letts., Springer Trans. • INSA Visiting Scientist Fellowship • JSPS Invitation Research Fellowship • Visiting Professor AGH Univ. of Sc. & Tech, Poland • RS- Newton Bhaba DST-BCL at Southampton University, UK • Research Internship (GE Medical) • Research students trained: • - SUNNY Oswego University, USA • - IMRE, Singapore • - NIG, Japan. Notable achievements • Overall progress • Procurement: • completed. • PDF: 2. • Ph.D.: 11 • M. Tech.: 18. • Collaboration: 4 MOU • (Industry) • In Pipeline: 3. • Product development jointly with industries: • Holystick Entertainment • PVT LTD, Mumbai • Sustainability: • - 2 projects granted • - 4 in pipeline • Sustainability • DBT (BT/PR3957/NNT/28/659/2013) • Rs. 38 lakhs. • Pracsol Health Pvt. Ltd. • Grants:15 lakhs • Others proposals submitted. • Incubation facility. • Short term training & Workshops. • Key Issues/ Concerns • Need of Developing more industrial collaborations. • Continuation of already trained research scholars’ fellowship and other supports • Transfer of knowhow and technology to products demands more time. Interaction/ relevance/ Economic advancements • Computer aided diagnosis tool – to complement conventional health care • Rice research will assist biotechnologists

  5. Committed targets: Center of Excellence • • Medical image capturing and image processing; • 3D image reconstruction; • • Design of bio-sensors and micro-fluidic channels; • Fabrication of bio-sensors and micro-fluidic chips; • Modeling of metabolic pathways.

  6. Long Term plan in a nutshell • Blood constituents • Adulterants in food • Cell count monitoring in blood. • Drug resistance microbes • Micro-fluidics channel & chip fabrication. • E-platform relating genotype phenotype relationship. • Developing Electro- • Optical Sensors to • characterize Plant Growth • and Development. • Optimization of Fertilizers • used in Plant. • 3D image • re-construction • 3D Functional mapping of Multi-Modal Images • Image analysis of • body constituents • Intelligent algorithm • development Bio-sensors, micro-fluidics Modeling Plant Cellular Physiology Imaging, Image processing Center of Excellence

  7. Financial Status

  8. Computational Facilities Computer Server Unit Working Space

  9. Plant Biological work Device Fabrication Units Plant growth chamber with controlled environment

  10. The CoE, CU Team Prof. Ajay Ghosh CoE Cordinator Dept. of Applied Optics and Photonics Area: Optical methods for non-invasive diagnosis Prof. Anjan Dasgupta Dept. of Biochemistry Area: Systems Biology Prof. Sanatan Chattopadhyay Dept. of Electronic Science Area: Microfludic Chip Design Prof. Sudip Kundu Dept. of Biophysics Area: Systems Biology Prof. Kallol Bhattacharya Dept. of Applied Optics and Photonics Area: Optical methods for non-invasive diagnosis Prof. Amlan Chakrabarti A.K. Choudhury School of IT Area: Computer Aided Diagnosis Prof. Nabendu Chaki Dept. of Computer Sc. and Engg. Area: Computer Aided Diagnosis

  11. CoE Team: Research Scholars

  12. Motivation • The basic health care facilities in our country are not adequately accessible to the remote areas and the cost of state-of-the-art healthcare system is far beyond the reach of majority of our population • Catalyze the process of collaboration and exchange between the faculty and healthcare professionals, thereby identifying more areas of innovative research and the development of demand based low cost diagnostic tools in addition to what is proposed • The interdisciplinary nature of healthcare needs can create a platform of unified research activity amongst scientists and technologists leading to new research contributions • Providing opportunity for students of the existing M.Sc. course in Biomedical Instrumentation and a proposed M. Tech. course in Biomedical Instrumentation, thereby stimulating them to take up research in this area • Objectives • Creation of an infrastructure to support research in developing non-invasive techniques for medical diagnosis • Prototype development for cost effective medical diagnostic tools to support the existing rural Health care system • To promote and strengthen industry-institute collaborative link for the necessity-driven research activities • Creation of opportunities of interdisciplinary M. Tech. and Ph. D. programmes for human resource development • Societal Impact (Conducting Seminars, Workshops, Refresher Courses etc.).

  13. SUMMARY of PROGRESS COE (Systems Biology and Biomedical Engineering), CU Interaction/ relevance/ Economic advancements Notable achievements • Patent Filed: 12 • Patent Granted: 3 • INSA Visiting Scientist Fellowship for visiting IIT KGP • JSPS Invitation Research Fellowship • Visiting Professor AGH Univ. of Sc. & Tech, Poland • RS- Newton Bhaba DST-BCL at Southampton University, UK • Key Issues/ Concerns • Need of Developing more industrial collaboration. • Continuation of already trained research scholars’ fellowship. • Transfer of knowhow and technology to products demands more time. • Computer aided diagnosis tool – to complement conventional health care • Rice research will assist biotechnologists • Overall progress • Procurement: • completed. • Publication: 117. • Patent: 15. • PDF: 2. • Ph.D.: 11 • M. Tech.: 18. • Collaboration: 4 MOU • (Industry) • In Pipeline: 3. • Product development jointly with industries: • Holystick Entertainment • PVT LTD, Mumbai • Sustainability: • - 2 projects granted • - 4 in pipeline • Human resource development • Journal Pub.: 60 • Conference Pub. 40 + 15 Book Chap + 3 Books • Research Internship (GE Medical) • Research students trained: • - SUNNY Oswego University, USA • - IMRE, Singapore • - NIG, Japan. • Representative Journals: • - NAR (I. F.: 9.1); Nature Scientific reports; IEEE Transactions, Appl. Phys. Letts., Springer Trans. • Sustainability • DBT India, Funding BT/PR3957/NNT/28/659/2013 Money sanctioned: Rs. 38 lakhs. • Pracsol Health Pvt. Ltd. A sum of 20 lakhs of Instrument Grant has been received. • Others proposals submitted. • Incubation facility is created. • Short term training & Workshops.

  14. Major Achievements • Publications • Journals: 60 Conferences: 40 Books: 3, Book Chapters-15 • Representative Journals: NAR , Nature Scientific reports; IEEE Transactions, IEEE ESL, Elsevier Micro., Appl. Phys. Letts., Springer Trans., Wiley, Journal of Applied Physics, Optical Engineering, Optiks, Inderscience, Journal of Nanoscience and Nanotechnology, .Mat.Chem etc. • M. Tech program on Biomedical Instrumentation started in the academic year 2015-2016. • Patents : Filed-12, Granted-3 • Funded Projects • UGC UPE-II funding in the area of Funding on Modern Biology , Novel Materials and Devices for Health Care and Environment Management • Other sanctioned projects: 2 • Pipeline: 4 • Invited Talks • International: 4 • National: 11 • Collaboration with Reputed International Institutes: Southampton University UK, AGH Univ. of Sc. & Tech, Poland , Kyushu Inst. Of Tech. Japan , - NIG, Japan, SUNNY Oswego University USA, IMRE Singapore, Univ. of Arad Romania.

  15. Major Achievements (Contd.) • Faculty • INSA Visiting Fellowship (2014) • JSPS Invitation Research Fellowship (2016) • Visiting Professor AGH Univ. of Sc. & Tech, Poland (2014 & 2016) • Student • Newton Bhaba DST-BCL Research Fellowship for performing research in neural signal processing at Southampton University, UK • MOU • CSIR, South Africa • Peerless Hospitex Hospital • Pracsol Health • JSV Innovation Private Limited • National Institute of Technology, Durgapur

  16. Pictures of COE LAB Coating Units Coating Units: Thermal Evaporation and Electron Beam Evaporation Rapid Thermal Processing Unit 3-stack Furnace

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