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BASES BIOFÍSICAS DE LA DIFUSIÓN

BASES BIOFÍSICAS DE LA DIFUSIÓN.

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BASES BIOFÍSICAS DE LA DIFUSIÓN

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  1. BASES BIOFÍSICAS DE LA DIFUSIÓN Brown R (1828). A brief account of microscopical observations made in the months of June, July, and August, 1827, on the particles contained in the pollen of plants and on the general existence of active molecules in organic and inorganic bodies. Phil Mag 4:161-173 Con la secuencia de DIFUSIÓN mediante RM se puede estudiar de forma exclusiva el movimiento microscópico intravóxel de las moléculas de agua en los tejidos

  2. DIFUSIÓN EN TEJIDO SANO H2O Doob JL (1942). The Brownian movement and stochastic equations. Ann Math 43:351-369

  3. CAUSAS DE RESTRICCIÓN DE LA DIFUSIÓN Delande C, de Zwart JA, Trillaud H et al. An echo-shifted gradient-echo MRI method for efficient diffusion weighting. Magn Reson Med 1999; 41:1000-1008 El movimiento del agua se restringe por: • Hipercelularidad • Barreras físicas (membranas celulares íntegras, que son hidrofóbicas) • Tortuosidad del intersticio celular • Edema intersticial • Fibrosis extracelular

  4. DIFUSIÓN EN LESIÓN HIPERCELULAR H2O Clark CA, Le Bihan D (2000). Watter diffusion compartmentation and anisotropy at high b values in the human brain. Magn Reson Med Dec; 44 (6):852-859

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