Before treatment

1. Responders 8 3,5 7 3 6 2,5 5 2 log viral load xULN 4 1,5 3 1 2 0,5 1 0 0 Before treatment 3+/-1 weeks 6+/-1 months 12+/-1 months After treatment Non responders 8 3,5 7 3 6 2,5 5 2 log viral load xULN 4 1,5 3 1 2 0,5 1 0 0 Before treatment 6+/-2 months 12+/-1 months After treatment Patients with viral breakthrough 3,5 8 7 3 6 2,5 5 2 log viral load xULN 4 1,5 3 1 2 0,5 1 0 0 Before treatment Before BT After BT After treatment Figure 1

2. 0.024 R13 preT 0.006 R14 preT 3a BT9 preT BT9 before bt BT9 after bt BT9 postT 0.059 0.006 NR15 preT NR15 M6 BT7 preT BT7 before bt BT7 after bt BT7 postT NR19 preT NR19 M4 NR19 postT 0.023 0.006 BT4 postT BT4 before bt BT4 before bt 0.032 0.006 BT8 preT BT8 before bt BT8 after bt BT8 postT BT4 preT BT4 after bt 0.004 0.005 NR16 preT NR16 M4 NR16 postT 1b BT2 preT 0.015 R12 preT 0.018 0.008 BT5 after bt BT5 preT BT5 postT BT6 preT 0.004 BT3 preT BT3 before bt BT3 after bt BT3 postT R11 preT BT6 after bt BT6 postT 0.008 NR17 preT NR17 M6 NR17 M11 NR17 postT 0.003 BT2 before bt BT2 after bt BT2 postT R10 preT NR18 M5 NR18 postT 0.004 BT1 preT BT1 after bt BT1 postT 0.012 1a NR15 postT NR18 preT 0.01 Figure : 2

3. BT8 preT 0.015 BT8 before bt BT8 after bt BT8 postT BT5 preT 0.047 BT5 after bt 0.013 BT5 postT NR15 preT 0.02 NR15 M6 NR15 postT BT6 after bt BT6 postT 1b NR17 preT NR17 M6 NR17 M11 NR17 postT NR16 preT 0.059 NR16 M4 NR16 M12 NR16 postT NR19 preT NR19 M4 NR19 postT BT7 postT BT7 after bt BT2 postT R10 preT 0.049 0.023 NR18 preT NR18 M5 0.009 1a NR18 postT BT1 preT 0.009 BT2 preT BT1 after bt BT1 postT BT4 preT 0.04 BT4 before bt (M5) BT4 before bt (M8) BT4 after bt R11 preT BT4 postT 0.013 R11 W4 BT6 before bt (1) 1b BT6 before bt (2) BT7 preT BT3 preT 0.016 BT3 after bt BT3 before bt BT3 postT BT6 preT R12 preT (1) R12 preT (2) 0.021 BT9 before bt R14 preT 0.01 0.101 0.021 0.011 3a R13 preT BT9 preT BT9 after bt 0.05 BT9 postT Figure 3