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Techniques

Techniques. Techniques. Trituration – reducing substances to fine particles by rubbing or grinding them with a mortar and pestle or on an ointment slab. Geometric dilution – gradually mixing equal amounts of ingredients together. . Techniques.

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Techniques

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  1. Techniques

  2. Techniques • Trituration – reducing substances to fine particles by rubbing or grinding them with a mortar and pestle or on an ointment slab. • Geometric dilution – gradually mixing equal amounts of ingredients together.

  3. Techniques • Levigation- after trituration; incorporating solid into a small amount of liquid (wetting agent) in which solid is not soluble. This makes solid more uniform throughout base and gets rid of gritty feeling. • Washing – removes drug from mortar by adding liquid agent to mortar to transport remaining drug to container

  4. Solutions • To mask taste of drugs • Unable to swallow tablets • Base solutions: cherry syrup, Ora-Sweet, simple syrup • Drug can be put in solution if it can dissolve completely • Check water solubility of drug (Remington) • Without formula or reference, may be easier to make medication as a suspension

  5. Suspensions • Two-phase system • Drug is uniformly dispersed in medium (shake well) • Drug is not soluble in liquid and will need to be incorporated in liquid through levigation • Advantages: • Taste-masking • Slows absorption • Solution > Suspension > Tablet/Capsule

  6. Suspensions • Suspending agent used commonly: • Oraplus(Paddock) • Syrspend (Fagron), Ora-Blend (Paddock) • Suspending agent to incorporate drug into liquid • Additional liquid vehicle for pleasant taste and to thin consistency • Ora-Sweet (Paddock), Cherry Syrup, Simple Syrup • Suspending agent usually 50% of total amount compounded • Liquid vehicle usually will be QS’d to total amount

  7. Suspensions • Example procedure for 30mL suspension • Weigh 5 ABC tablets with torsion balance • Triturate tablets into fine powder with glass mortar • Levigate powder with 15mL of Ora-Plus • Transfer product to conical graduate • Wash mortar with Ora-Sweet • QS with Ora-Sweet in conical graduate to 30mL • Transfer to 1 oz amber bottle • Label and dispense with auxiliary labels

  8. Semi-Solid Preparations • Lotions – Most water content (mL) • Creams – half oil and half water (g) • Ointments – 80% oil and 20% water (g) • Use pill tile or ointment paper to incorporate ingredients into base • Spatula to mix and transfer product • Well technique – create a well in the middle of your semi-solid base and add desired liquid in well to begin incorporation in base

  9. Semi-Solid Preparations • Example procedure: • Measure X liquid with graduated cylinder • Weigh cream and Y powder with digital balance • Transfer cream to pill tile • Mix in X liquid into cream using well technique • Levigate Y powder with cream • Mix ingredient thoroughly in cream • Transfer to ointment jar • Label and dispense compound

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