بسم الله الرحمن الرحيم

1. بسم الله الرحمن الرحيم

2. vasculitis BY Dr.Nesreen Kotb

3. What Is Vasculitis ?

4. What is the Causes of Vasculitis ?

5. Pathogenesis Of Vasculitis • T Cell mediated . • Immunecomplex mediated Antibodies • to antigensthat are integral components • of vessel wall . • ANCA associated vasculitis .

6. Symptoms of vasculitis • Fatigue • Weakness • Fever • Abdominal pain • Proteinuria , hematuria , casts • Nerve problems (numbness , weakness) • Skin rash

7. Classification of Vasculitis

8. Vasculitis • Large vessel vasculitis • Giant vessel vasculitis • Takayasu vasculitis • Medium sized vessel vasculitis • Polyarteritis nodosa • Kawasaki disease • Small vessel vasculitis • ANCA associated • None ANCA associated

9. Small vessel vasculitis • None ANCA associated • Immune complex vasculitis • -Henoch Schonlein purpura • -Cryglobulinemic vasculitis • -Lupus vasculitis • -Rheumatoid arthritis • -Good pasture’s syndrome • -Behcet disease • Inflammatory Bowel disease • vasculitis. • Paraneoplastic small vessel • vasculitis • ANCA-associated • Wegener’s granulomatosis • Microscopic polyangiitis • Churg- Strauss syndrome

10. ِ ANCA associated small vessel vasculitis • Granuloma present • Asthma and eosinophilia • (churg-strauss syndrome) • No eosinophilia • (wegener’s granulomatosis) • No granuloma • Microscopic polyangiitis

11. Diagnosis Of Vasculitis

12. Treatment Of Vasculitis