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Characteristics of primary syphilis

Characteristics of primary syphilis. single, nonpainful chancre are the site of sexual contact with infected individual. secondary (systemic) characteristics of syphilis. skin rash that presents 1 to 6 months after primary infection

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Characteristics of primary syphilis

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  1. Characteristics of primary syphilis • single, nonpainful chancre are the site of sexual contact with infected individual.

  2. secondary (systemic) characteristics of syphilis • skin rash that presents 1 to 6 months after primary infection • appears on trunk as macules becomes maculopapular or papulosquamous • characteristically appears on hands and soles of the feet • spirochetes can involve hair follicles, producing patchy alopecia of the scalp. • (most severe stage) neurosyphilis. • ocular syphilis is a form of neurosyphilis

  3. Lab tests for syphilis • confirm infection with T pallidum. • venereal disease research laboratory (VDRL) • rapid plasma regain (RPR) • fluorescent treponemal antibody absorption (FTA-ABS) • T pallidum particle agglutination (TP-PA)

  4. Lab tests for active case of syphilis • venereal disease research laboratory (VDRL) • rapid plasma regain (RPR)

  5. Lab tests for lifetime exposure to syphilis • fluorescent treponemal antibody absorption (FTA-ABS) • T pallidum particle agglutination (TP-PA)

  6. patients with syphilis are frequently co-infected with _____ • human immunodeficiency virus (HIV)

  7. current therapy for HIV-infected individuals • highly active antiretroviral therapy (HAART)

  8. the primary and secondary syphilis rate has recently increased in what population? • men who have sex with men (MSM) • In 2004, ~64% of all primary & secondary syphilis were among MSM.

  9. Ocular symptoms of syphilis (case in article) • flashes & floaters • black “spot” inferiorly OS for 2 weeks • (systemic symptoms) • rash • scaly papules on soles of feet & palms • alopecia • joint pain of left knee

  10. the ocular manifestations of syphilis … • mimic a host of infectious and noninfectious conditions • aka “Great Imposter”

  11. differential diagnosis for bilateral, granulomatousuveitis. • tuberculosis • sarcoidosis • toxoplasmosis • Lyme disease • Vogt-Koyanagi-Harada syndrome • cytomegalovirus (CMV) • herpes zoster

  12. Prior to penicillins, _____ was the most common cause of uveitis? • ocular syphilis • uveitis is typically: • bilateral • granulomatous

  13. ocular syphilis & HIV can … • accelerate the natural course of syphilis • alter the clinical presentation of syphilis • increase ocular involvement, neurosyphilis, treatment failure and relapse

  14. Normal treatment of neurosyphilis • Acceptable treatment of neurosyphilis for HIV patient • IV penicillin G benzathine for 14 days • IV ceftriaxone (2 grams per day) for 21 days

  15. Ocular involvement in syphilis • is diagnostically significant • represents severity of syphilis

  16. Historically, HIV patients will seek OD care for _____. • CMV retinitis.

  17. a diagnosis of ocular syphilis should be suspected … • patients present with bilateral uveitis

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