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Potential Therapeutic Effects of Lipase Inhibition on Acne and Corneal Repair

Explore how inhibiting lipase can treat acne vulgaris caused by Propionibacterium acnes and aid in corneal wound healing. Investigate the potential benefits of Sacchachitin in tyrosinase inhibition and tissue regeneration. References included.

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Potential Therapeutic Effects of Lipase Inhibition on Acne and Corneal Repair

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  1. Extension能否經由抑制 Lipase來治療青春痘? Acne vulgaris 由Propionibacterium acnes引起 Lipase

  2. Victoria Blue B

  3. SA CK MTT test for inhibition of P.acnes by SACCHACHITIN

  4. Tyrosinase inhibition? 美白?

  5. Melanoma cell line CK SA 0.1% Melanin production

  6. Conea repair • 眼角膜創傷治療 • 不溶於水，如何成為眼藥水? • 微米化(直徑2 mm)

  7. 微粒化SACCHACHITIN

  8. SEM SACCHACHITIN

  9. SEM Micronized SACCHACHITIN

  10. MMP: Rabbit B

  11. Fluorescein staining: Rabbit B Experimental Group Control Group

  12. Normal Cornea

  13. Experimental Group 200X 96hr Normal Conea Control Group 200X 96hr

  14. SACCHACHITIN 之劑型 膜 微粒化懸浮液 軟膏

  15. Tissue regeneration Cells 細胞 Growth Factors Biomaterials 生長因子 生物材料

  16. References • 1.Su, C.H., C.H. Sun, S. W. Juan, C. H. Hu, W. T. Ke, M. T. Sheu 1997 • Fungal mycelia as the source of chitin and polysaccharides and their application as skin substitutes. Biomaterials 18:1169-1174 • 2. Su CH, Sun CS, Juan SW, Ho HO, Hu CH and Sheu MT 1999 • .Development of fungal mycelia as skin substitutes: Effects on the wound healing process. NTJM.(1):31-39. • 3. Su CH, Sun CS, Juan SW, Ho HO, Hu CH and Sheu MT 1999 • Development of fungal mycelia as skin substitutes: Effects on wound healing and fibroblast. Biomaterials.(20):61-68. • 4. Huang WS, Fang CL, Su CH , Lai WF , Chang WC, and Tsai YW 2001 • Cytotoxicity and immunogenecity of SACCHACHITIN and its mechanism of action on skin wound healing. J. Biomedical Research.(56):93-100. • 5. Hung WS, Lai WF, Leu B, Su CH, Fang CL, Tsai.YH 2004 • Effect of SACCHACHITIN on keratinocyte proliferation and the expressions of type I collagen and tissue-transglutaminase during skin wound healing. Journal Biomedical Material Research Part B: Applied Biomaterials.(70B):122-129. • 6. Su CH, Liu SH, Yu SY, Hsieh YL, Ho SO, Hu CH, Sheu MT 2005.Development of fungal mycelia as a skin substitute:Characterization of keratinocyte proliferation and matrix metalloproteinase expression during improvement in the wound-healing process. Journal of Biomedical Materials Research Part A.(72A):220-227.

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