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Ecological Genetics

Instructors. Dr. Kim Hughes (Animal Biology)(Almost) Dr. Beth Ruedi, Program in Ecology and Evolutionary Biology. Books. 1. A Primer of Ecological Genetics, by J. Conner and D. Hartl2. Evolutionary Analysis, by S. Freeman, and J. Herron (cheaper to purchase used copies online (Alibris, Bookfind

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Ecological Genetics

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    1. Ecological Genetics IB 405

    2. Instructors Dr. Kim Hughes (Animal Biology) (Almost) Dr. Beth Ruedi, Program in Ecology and Evolutionary Biology

    3. Books 1. A Primer of Ecological Genetics, by J. Conner and D. Hartl 2. Evolutionary Analysis, by S. Freeman, and J. Herron (cheaper to purchase used copies online (Alibris, Bookfinder, Amazon, etc.)

    4. Pre-requisites IB 201 or equivalent (Genetics and Evolution) http://www.life.uiuc.edu/ib/201/index.html MCB 150 or equivalent (Molecular Genetics) Statistics Calculus Population Genetics Review Material provided in first set of lecture notes and on the IB 201 web site.

    5. Course Policies NO MAKEUP EXAMS HW assignments posted on the course web site. Final: 8:00-11:00 am Friday, Dec. 13, in this room and a second room TBA. Reading assignments, recommended problems, lecture notes and ppt files on the course web site.

    6. Grading Four HW assignments 240 pts Two exams (One Midterm and a 500 pts Comprehensive Final Exam) Reading and Discussion of 160 pts Primary Literature (Peer Reviewed and Graded) Advanced Topics Graduate Students: Presentation 100 pts based on current primary literature Undergraduates: Assignments based on current primary literature Total 1000 pts

    7. Extra Credit No extra credit, but your participation in Discussion is worth 150 pts. If you do the assigned readings and participate enthusiastically in discussions, you can get nearly all of these points.

    8. Course Outline Behavior & Sexual Selection Behavior Genetics Life History Evolution Sex and Recombination Conservation Genetics Advanced Topics Introduction Genetic Variation Evolutionary Processes Natural Selection on Genotypes Complex Phenotypes Natural Selection on Phenotypes Molecular Evolution

    9. Course Web Site http://www.life.uiuc.edu/ib/405/index.html

    10. Lecture and ppt downloads Rec Problems Book

    11. Do Bring a calculator and scrap paper to class Download lecture notes before class Do recommended problems: you will see them again! Read the assigned material before class Participate in class discussion

    12. Don’t Furiously take notes during class Put off the homework until the last minute Put off doing recommended problems until just before the exam

    13. What is Ecological Genetics? Definition 1: Genetics of ecologically important traits: Ecologically important traits are those that determine an organism’s adaptation to its environment (traits that affect survival and reproduction) Examples?

    14. What is an adaptation? A phenotypic trait that has evolved to help an organism deal with its environment

    15. Examples

    16. Example: growth

    17. Behavior

    18. Physiology

    19. What is Ecological Genetics? Definition 2: Study of the processes of evolution occurring in present-day natural populations What are the processes that cause evolution?

    20. First, what is evolution? Evolution: change in allele (or genotype) frequencies over time Contrast with: “change over time”. Phenotypic evolution: change in the mean or variance of a trait (phenotype) that is due to changes in allele frequencies

    21. Processes causing evolution? Natural selection Genetic drift Mutation Gene flow Non-random mating (e.g., inbreeding)

    23. Review of some basic genetic concepts

    24. Central Dogma of Molecular Biology

    25. Genes: DNA-->RNA

    26. Transcription and RNA Processing

    27. Coding DNA Exons code for proteins, tRNA, rRNA

    28. Protein-Coding genes: mRNA->Protein

    29. Genetic Code Based on mRNA sequence, not DNA sequence 21 amino acids 64 possible codons Code is degenerate Often 3rd base position does not matter

    30. Compare and contrast these terms Transcription Translation mRNA tRNA rRNA Intron Exon Single-copy DNA Repetitive DNA Pseudogene

    31. Mutation: categories that are important for function

    32. Self-Quiz

    33. Compare and contrast these terms Haploid Diploid Genotype Phenotype Pleiotropy Epistasis Linkage Recombination Independent assortment

    34. Compare and contrast these terms Allele frequency Genotype frequency Heterozygosity Polymorphism Hardy-Weinberg equilibrium Hardy-Weinberg proportions Genetic Drift Gene Flow Mutation Recombination

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