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p<0.05

B. A. p<0.001. p<0.05. p<0.01. 90. 100. p<0.01. p<0.001. 70. 40. 60. Cyp7a1 mRNA (AU). Shp mRNA (AU). 10. Control. CA. 30. 5. 0. 0. Control. CA. Control. CA. Control. CA. Control. CA. 20. Mrp3 +/+. +/+. -/-. Mrp3. Mrp3. 15. Mrp4 mRNA (AU). 10. 5. p<0.05.

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p<0.05

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  1. B A p<0.001 p<0.05 p<0.01 90 100 p<0.01 p<0.001 70 40 60 Cyp7a1 mRNA (AU) Shp mRNA (AU) 10 Control CA 30 5 0 0 Control CA Control CA Control CA Control CA 20 Mrp3+/+ +/+ -/- Mrp3 Mrp3 15 Mrp4 mRNA (AU) 10 5 p<0.05 18 p<0.05 Mrp3-/- 0 15 Control CA Control CA 12 +/+ -/- Mrp3 Mrp3 Bsep mRNA (AU) 9 +/+ +/+ -/- -/- Mrp3 Mrp3 Mrp3 Mrp3 6 3 0 Control CA Control CA Supplementary Fig.1

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