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Infection of parasite nematodes confounds vaccination efficacy (Urban et al . 2007)

Infection of parasite nematodes confounds vaccination efficacy (Urban et al . 2007). Journal Club of Veterinary Medicine, 18 October 2007. Ingeniøren , 13 October 2007. If you want to be innovative? The get rid of the laid back attitude!

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Infection of parasite nematodes confounds vaccination efficacy (Urban et al . 2007)

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  1. Infection of parasite nematodes confounds vaccination efficacy (Urban et al. 2007) Journal Club of Veterinary Medicine, 18 October 2007

  2. Ingeniøren, 13 October 2007 If you want to be innovative? The get rid of the laid back attitude! It has to hurt a little to participate in an innovation project. If it is too fun and cozy, it does not move, concludes a ph.d.-dissertation.

  3. Immune System

  4. Adaptive Immune System

  5. T-cell development

  6. Cytokines can prime of T helper cells development Th0 INF IL12 TNF IL4 IL13 IL10 Th1 Th2 Intracellular Extracellular

  7. “Infection of parasite nematodes confounds vaccination efficacy” Veterinary Parasitology. 2007 August 19; 148(1): 14-20 (Urban et al. 2007) General vaccination strategy + Vaccination Challenge (2nd vaccination) Antibodies (IgG1, IgG2) Cytokines

  8. “Infection of parasite nematodes confounds vaccination efficacy” Veterinary Parasitology. 2007 August 19; 148(1): 14-20 (Urban et al. 2007) Mouse model + + Nematode Vaccination Challenge (2nd vaccination) Heligomosomoides polygyrus Plasmodium yoelii (malaria antigen, mice) • IL3 • IL4 • IL5 • IL9 • IL13 • IgG1 & IgE INF IL4 IL13 IL10 TGF

  9. “Infection of parasite nematodes confounds vaccination efficacy” Veterinary Parasitology. 2007 August 19; 148(1): 14-20 (Urban et al. 2007) Pig model + + Nematode Vaccination Challenge (2nd vaccination) Ascaris suum Mycoplasma hyopneumonia (commercial killed vaccine) • 33% specific antibody response to M. Hyopnemonia. • Serum conversion did not exceed 78 %. • More lung pathology • Weak Th1 (lungs) • Th2 (intestine)

  10. Parasitic infections as medicine An inflammatory bowel disease Chron’s Disease (regional interitis) Autoimmune disease Th1-dominated Th2

  11. Thank you for listning!

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