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Ben Lam, Srinivas Rao, Alvin Young, Lulu Cheng,Dennis Lam Hong Kong Eye Hospital Department of Ophthalmology and vi

Modified Osteo-Odonto Keratoprosthesis (MOOKP) in patients with severe anterior segment disease: Our Hong Kong Experience Bone – Tooth Cornea replacement 骨齒人工角膜. Ben Lam, Srinivas Rao, Alvin Young, Lulu Cheng,Dennis Lam Hong Kong Eye Hospital

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Ben Lam, Srinivas Rao, Alvin Young, Lulu Cheng,Dennis Lam Hong Kong Eye Hospital Department of Ophthalmology and vi

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  1. Modified Osteo-Odonto Keratoprosthesis (MOOKP) in patients with severe anterior segment disease: Our Hong Kong ExperienceBone – Tooth Cornea replacement骨齒人工角膜 Ben Lam, Srinivas Rao, Alvin Young, Lulu Cheng,Dennis Lam Hong Kong Eye Hospital Department of Ophthalmology and visual science /CUHK (no financial interest)

  2. Purpose • To evaluate the efficacy and safety of Modified Osteo-Odonto Keratoprosthesis (MOOKP) in Hong Kong patients with severe anterior segment disease.

  3. Methods • Retrospective review of all nine patients with MOOKP performed at Hong Kong Eye Hospital from June 2005 to Oct 2007. • All patients had poor vision bilaterally as a result of chemical injury, ocular cicatricial pemphigoid (OCP) or multiple corneal graft failure.

  4. Methods • In contrast to classic OOKP, Our MOOKP consists of 3 stages. • The first stage involves the removal of iris and lens, as well as the preparation of the osteo-dental lamina complex.

  5. Methods • The second stage involves the preparation of buccal mucosal surface • Third stage involves implantation of complex.

  6. Methods Outcome measures included • post-operative visual acuity • complications such as glaucoma, retinal detachment and wound-related problems

  7. Results • The mean patients’ age was 53.6 years (ranges 25 – 75 years). • Six patients suffered from chemical burn, two from OCP and one had history of multiple corneal graft failure. • The mean post-operative follow-up was 18.4 months (range 6- 28 months).

  8. Results • The pre-operative best corrected visual acuity (BCVA) ranged from hand movement to light perception • Post-operative Snellen BCVA ranged from 0.4.to 0.7 except for three eyes.

  9. Results • One eye developed choroidal effusion and vitreous haemorrahge. One eye developed retinal detachment and pale disc .The visual acuity was light perception and no light perception respectively. • One eye also developed overgrowth of the mucosa over the cylinder which required excision. • Two eye had pale discs post operatively compromising the visual potential

  10. Conclusion • Despite the complex nature of the operation and possible complicationsMOOKP offers the hope of visual improvement for patients with severe anterior segment disease. Future studies with longer follow-ups to evaluate its efficacy and safety are warranted.

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