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Understanding the Innate Immune Response: Inflammation and Infection Detection

Explore the innate immune system's response to infection, including inflammation, recruitment of immune cells, phagocytosis, and the role of various receptors and soluble molecules.

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Understanding the Innate Immune Response: Inflammation and Infection Detection

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Presentation Transcript

  1. Overview: Innate Immune Response

  2. Inflammation Recruitment from the bloodstream

  3. Inflammation Phagocytosis of a bacterium

  4. Inflammation

  5. Inflammation

  6. Cells involved in innate immunity •Neutrophils •Macrophages •Dendritic cells •Natural killer cells

  7. Soluble Molecules •Proinflammatory cytokines: •IL-1 •TNFa •Antimicrobial peptides •Acute phase response (APR) and acute phase response proteins •complement proteins •C-reactive protein (CRP) •Mannose-binding lectin (MBL)

  8. Receptors Detect Infection

  9. Receptors Detect Infection •Classification of PRRs: a) signaling b) endocytic •Membrane bound: Toll-like receptors (TLR) C-type lectin receptor (CLR) Scavenger receptors (SRs) Lipopolysaccharide receptor (LPR) •Cytoplasmic: NOD-like receptors (NLR) •Secreted: Mannose-binding lectin (MBL) Complement receptors C-reactive protein (CRP) LPS-binding protein (LBP)

  10. Receptors Detect Infection

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