1 / 19

BioInspired Nanotechnologies: from concept to applications TD 1003 Start date: 2/11/2010

BioInspired Nanotechnologies: from concept to applications TD 1003 Start date: 2/11/2010 End date: 1/11/2014 Year : 3. AIME STREHLITZ Chair Vice Chair CNRS / France Germany. Presentation Maria Minunni.

fadhila
Download Presentation

BioInspired Nanotechnologies: from concept to applications TD 1003 Start date: 2/11/2010

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. BioInspired Nanotechnologies: from concept to applications TD 1003 Start date: 2/11/2010 End date: 1/11/2014 Year: 3 AIME STREHLITZ Chair Vice Chair CNRS / France Germany Presentation Maria Minunni http://www.bioinspired-nano.eu/en/

  2. Background / Problem statement: • Converging development of molecular biology and bioengineery, instrumentation down to the nm scale and technological centers. • The Action wants to bring Bioinspirednanosystems and nanomaterials in the field of nanotechnology and to combine Bioinspired bottom up and top down fabrication methods. reminder of MoUobjectives (Memorandum ofUnderstanding) /Research directions: • design of multi-scale structures based on nm building blocks. • determination of steps and levels of integration, (ICT) • Engineering the interface properties from molecular scale up to micrometres. http://www.bioinspired-nano.eu/en/ Scientific context and objectives (1/2)

  3. Scientific context and objectives (2/2) • Research directions:An InterdisciplinaryNetwork: • Helping researchers to meet: 9 meetings (May 2013): Bilbao, Bordeaux, Linköping, Nijmegen, Brussels (2), Heraklion, Bratislava, Sitges; Bioinspired Day sessions in International Conferences. • Developing collaborations (STSM): 6 (2011) + 7 (2012) + 5-8 (2013) • Building cooperative projects (see WG initiatives) • Mixing EU researchers with different background: instrumentation, technology, biology, chemistry and hybrids materials… • Developing the field of DNA and protein-peptide nanotechnology, with part of the goal directed toward Synthetic Biology. 3

  4. Biomaterials with 3 sub-topics: Virus, proteins and peptides, DNA and aptamers. (Jan Van Hest NL (C), Anna Mitraki GR, Thierry Michon FR). 45 members • Biomechanisms and molecular modeling: Interface properties and interaction between molecules and nano-objects. Coupled with instrumentation (Alain Estève FR). 20 members. • Technology Integration: assembling nano blocks and hybrid systems (organic-inorganic, polymer network and proteins…) (Maria Farsari GR). 24 Members • BioDevices Demonstrators and applications. At this moment mostly focused on biosensors(JosepSamitier ES ). 14 members. • http://www.bioinspired-nano.eu/en/ Working groups

  5. WelcomeA. Turner • 9.10-9.40 • Regenerative medicine and collaborative activities at LiU • M. Griffith • 9.40 -10.10 • DNA detection in a droplet microfluidic devices • L. M. Zanoli, M. Licciardello, R. D’Agata, A. Calabretta, C. Lantano, R. Marchelli, R. Corradini, • G. Spoto • 10.10-10.40 • Molecular diagnostic label-free biosensing platform based on DNA conformation-probing • G. Papadakis, A. Tsortos, E. Gizeli • 10.40-11.10 • Nucleic acids on electrodes for detection of DNA and DNA binding molecules • F. Lisdat • 11.10-11.30 • Coffee • 11.30-11.50 • Low-voltage and electrolysis-free electroosmosis for microfluidic applications • N. D. Robinson • 11.50-12.20 • Feasibility Study: Simultaneous microfabrication and enzyme encapsulation in SU-8 films for fluorescence-based phenol Biosensor • S. D. Psoma, P. D. van derWalb, N. F. de Rooij • 12.20-12.40…1,5 days and MC meeting Linköping April 26 2012 « Distributed Diagnostic » http://www.bioinspired-nano.eu/en/

  6. ComeniusUniversityCongress Center, Bratislava, COST meeting, organizer TiborHianik, 8-10 April, 2013 The Workshop tookplace at ComeniusUniversityCongress Center, Druzba. Itconsisted of6invitedplenarylectures, 18 short oralpresentations and 13 posters. The invitedspeakerswereleadingscientists in the respectivefield. 3of6speakers (50%) wereexternalexpert so that do notbelongtothis COST action. The followingmainscientifictopicswerepresented and discussed: • 1. propertiesofbiomimeticstructures, suchaslipidfilms and thatcoveredbybacterialS-proteins, • 2. polymerstabilizedlipidfilmsformed on nanostructures and theirapplication in biosensing, • 3. applicationoflipidvesiclesmodifiedbycellreceptors in biosensing, • 4. folding and cooperative propertiesof DNA origami, • 5. properties and applicationsof DNA aptamers, • 6. applicationof DNA technology in biosensing, • 7. peculiaritiesofelectrical and optical detection methods • 8. properties and biomedicalapplicationsofnanoparticles. • and MC meeting

  7. 131 participants from 28 countries

  8. “Peptide and protein based materials “ September 13th and 14th 2012, NijmegenOrganizersJ. van Hest and D. Löwik 4 Keynote lectures: Prof. R. Quinlan « proteinchaperone machines and intermediate filaments ». Prof. J. Schneider « self-assembled peptide based hydrogels » Prof. N. Cameron « peptides as building blocks for new polymericmaterials » Prof. J. Cornelissen « ChemicalVirology » & 15 oral contributions with 45 participants;

  9. Detection • Objectives: Detecting-Molecules: linkers & highly specific sensors.- Sensitivity Enhancement: developing confined chemical reactions set-up.- Signal Transducing method: electrochemical devices- Integrated Platform: combining linkers, sensors, nanoreactors and electronic/electrochemical devices.- Improving the Relationship with companies: Procter & Gamble and Radiometer. Read Out Translation WG3 Meeting Nanosbios Coordinator: Roy Quinlan, Brussels, October 26, 2012

  10. Several aspects were discussed : - VNPs from plants : various shapes for various applications (rod-like, filamentous, pseudo-spheres) - VNPs as biomolecules carriers (enzymes, fluorophores) inside and outside. - VNPs as building blocks for 2 and 3 D materials (tissues engineering, detoxification of water, multilayers of functionalized VNPs) - VNPs integrated in devices (biofuel cells, diagnosis chips...) WG 1 Meeting Virus-likeparticles as nano-carriers : news and views Coordinator: Thierry Michon, Brussels, December 18, 2012

  11. 13 Conferences on: • 3D nanostructurations with Laser, • Cell Mechanical properties • Natural and artificial assembly of peptides and protein fibres. • Various Drug delivery systems. • Instrumentations for biological systems. • Aptamers as a tool for biosensors. Bioinspiredmaterials design and applications OCTOBER 12-13, 2012 Heraklion Greece, Organizers Maria Farsari & Anna Mitraki

  12. 14 Use of COST Instruments

  13. Bilbao, Spain April 14-14, 2011Kick off 38 short talks, BioinspiredNanosystems and Nanomaterials,  Bordeaux, France 14 – 17 Nov. 2011 22 tutorials and 18 orals, organizer J.J. Aimè Linköping, Sweden, April 26 2012,  Distributed Diagnostic », A.P.F. Turner Heraklion, Crete18 October, organizer M: Frasari, A. MItraki Bratislava, Slovakia, 8-10 April, 2013-04-09, “Biomimeticstructure and DNA technology in biosensing”, organizer T. Hianik Sitges (Barcelona), Spain,16 May 2013, organizer M. Minunni Leipzig, Germany, 8-9 October 2013, "Nano-scalesarrangementsofproteins, aptamers and othernucleic acid structures - and theirpotentialapplications”, organizer Beate Strehlitz and Fred Lisdat,

  14. Significant Highlights in Science or Networking (1/3) COST Action TD 1003 has enforced collaborations between EU teams already set before the action started and created new ones. DNA and Protein-peptide nanotechnology should emerge. 16 16

  15. Significant Highlights in Science or Networking (2/3) • A technological Breakthrough: JACS publication Univ Aarhus-iNANO_CNRS-Univ Bordeaux leading to a better understanding on how DNA Origami platform are fabricated. 17 http://www.bioinspired-nano.eu/en/

  16. (3/2) Surface Plasmon Resonance (SPR) RU Arrayof Light Sensitive Diodes (LSD) • A technological Breakthrough: • JPC Lett publication UNI Firenze & Catania, • a perpsective on the emerging SPR imaging. Sensorgram Biochip Time Sensorgrams Sensing Area Time Charge Coupled Device (CCD) SPR imaging (SPRi) ΔR% Sensing Areas: Regions of Interest (ROIs) Biochip

  17. http://bioinspired-nano.eu/en/

More Related