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Stock Slides. contains groups, etc. useful in making slides. Pharmacokinetic-Pharmacodynamic Modeling of Vg Formation Using Indirect-Response Models. EE2-Estrogen Receptor complex. k DNA. k on. EE2. k off. . . Vg. +. “transit compartments”. Receptor Binding, Nuclear Translocation
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Stock Slides contains groups, etc. useful in making slides.
Pharmacokinetic-Pharmacodynamic Modeling of Vg Formation Using Indirect-Response Models. EE2-Estrogen Receptor complex kDNA kon EE2 koff Vg + “transit compartments” Receptor Binding, Nuclear Translocation & Vg Synthesis Biomarker Dosimetry Chemical Dosimetry Pharmacokinetics Pharmacodynamics1 Excretion of Vg 1Xu et. al. (1995). J. Pharmacokinetics and Biopharmaceutics23:163-181.
Vg concentration-time profile after EE2 injection (initial 100 hrs)
Vg, EE2 concentration-time profiles after IA injection of EE2 t½= 132 hrs t½= 30.7 hrs t½= 20.1 hrs