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ATP Synthase: Subunit Gamma

ATP Synthase: Subunit Gamma. Lauren Ivey. Resveratrol binds to gamma, alpha, beta Hydrolysis and synthesis Hydrophobic pocket between beta and gamma subunit Gamma Because beta most likely more highly conserved Alpha, beta in larger scale project. ATP synthase animation. Grape to blueberry.

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ATP Synthase: Subunit Gamma

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  1. ATP Synthase: Subunit Gamma Lauren Ivey

  2. Resveratrol binds to gamma, alpha, beta • Hydrolysis and synthesis • Hydrophobic pocket between beta and gamma subunit • Gamma • Because beta most likely more highly conserved • Alpha, beta in larger scale project

  3. ATP synthase animation

  4. Grape to blueberry

  5. Blueberry hits from grape • TAGTCCGAAACCGGATGAAGAGTGTGAAGAATATCCAGAAAATTACTAAGGCCATGAAAA • TGGTTGCAGCATCTAAGCTGCGAGCTATTCAAGTTAGGGCTGAGAATTCCCGTGGCCTAT • GGCAGCCATTTACTGCACTTCTTGG • GTTCTGTTCAATGCTGTCTTGGAGAATGCTACCAGTGAGCAAGGAGCAAGGATGTCTGCC • ATGGATAGCTCCAGCAGAAATGCTGGAGACATGCTTGACCGCCTCACGCTTACTTATAAC

  6. Blueberry to bovine

  7. Grape to Bovine

  8. Blueberry to human

  9. Next Steps • Amino acid sequences • Bovine, grape, blueberry • Beta and alpha • Interactions with resveratrol structure • Hypothesis: No hydrophobic pocket and resveratrol does not bind to ATP synthase in blueberry and grape

  10. Why do we care? • cardiovascular disease and neurological disorders • cardiac ischemia- • Prevents hydrolysis of ATP • apoptosis • Selective induction • Normal cells change binding sites Gledhill, J.R et al. Mechanism of inhibition of bovine F1-ATPase by resveratrol and related polyphenols. PNAS. 2007; 104(34): 13632-13637.

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