Hajduk and Greer Nature Reviews Drug Discovery 6 , 211 –219 (March 2007) | doi:10.1038/nrd2220

Oct 15, 2014

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Hajduk and Greer Nature Reviews Drug Discovery 6 , 211 –219 (March 2007) | doi:10.1038/nrd2220.

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Hajduk and Greer Nature Reviews Drug Discovery 6 , 211 –219 (March 2007) | doi:10.1038/nrd2220

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Hajduk and Greer Nature Reviews Drug Discovery6, 211–219 (March 2007) | doi:10.1038/nrd2220

DRUG DISCOVERY – NEW DRUG DEVELOPMENT PROCESS

DRUG DISCOVERY – NEW DRUG DEVELOPMENT PROCESS. BY. Dr. BASAVARAJ K. NANJWADE. Department of Pharmaceutics K L E UNIVERSITY JN MEDICAL COLLEGE BELGAUM – 590010 E-mail: bknanjwade@yahoo.co.in. DRUG.

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Business Value of SW in Drug Discovery

Business Value of SW in Drug Discovery. Eric Neumann, W3C HCLSIG co-chair Teranode Corporation F2F Cambridge MA. Tox/Efficacy. New Regulatory Issues Confronting Pharmaceuticals. ADME Optim. from Innovation or Stagnation , FDA Report March 2004. Drug Discovery Costs.

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Assembly of CasA and CasB to the six-CasC helix mediated by the unique Asp-Arg/Lys-Trp triad. H Zhao et al. Nature 000 , 1 - 4 (201 4 ) doi:10.1038/nature 13733 Note: This figure is from a near-final version AOP and may change prior to final publication in print/online.

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Putative active site of DgkA complete with lipid and Mg 2+ -ATP substrates and activating zinc. D Li et al. Nature 000 , 1 - 4 (2012) doi:10.1038/nature 12179.

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NNMT expression is increased in WAT and liver of obese and insulin-resistant mice. D Kraus et al. Nature 508 , 258-262 (2014) doi:10.1038/nature 13198.

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NPSG circulation and N* distribution with sample locations. OA Sherwood et al. Nature 000 , 1 - 4 (201 3 ) doi:10.1038/nature 12784.

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Kaye and Krum Nature Reviews Drug Discovery 6 , 127 – 139 (February 2007) | doi:10.1038/nrd2219

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Free subunits capture subunits docked at the export gate through head-to-tail linkage of terminal helices. LDB Evans et al. Nature 000 , 1 - 4 (201 3 ) doi:10.1038/nature 12682.

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Yin et al. Nature Reviews Neuroscience 7 , 464 – 476 (June 2006) | doi:10.1038/nrn1919

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Profile showing the spatial variation of the vibrational signal. OL Krivanek et al. Nature 514 , 209 - 212 (201 4 ) doi:10.1038/nature 13870.

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Hajduk and Greer Nature Reviews Drug Discovery 6 , 211 –219 (March 2007) | doi:10.1038/nrd2220

Hajduk and Greer Nature Reviews Drug Discovery 6 , 211 –219 (March 2007) | doi:10.1038/nrd2220

Presentation Transcript

DRUG DISCOVERY – NEW DRUG DEVELOPMENT PROCESS

Enhancing the drug discovery pipeline – a perspective on CV drugs

Business Value of SW in Drug Discovery

J Kim et al. Nature 000 , 1 - 4 (2013) doi:10.1038/nature 12180

H Zhao et al. Nature 000 , 1 - 4 (201 4 ) doi:10.1038/nature 13733

Drug Discovery &amp; Development

D Li et al. Nature 000 , 1 - 4 (2012) doi:10.1038/nature 12179

JN Moum et al. Nature 000 , 1 - 4 (201 3 ) doi:10.1038/nature 12363

D Kraus et al. Nature 508 , 258-262 (2014) doi:10.1038/nature 13198

OA Sherwood et al. Nature 000 , 1 - 4 (201 3 ) doi:10.1038/nature 12784

Kaye and Krum Nature Reviews Drug Discovery 6 , 127 – 139 (February 2007) | doi:10.1038/nrd2219

LDB Evans et al. Nature 000 , 1 - 4 (201 3 ) doi:10.1038/nature 12682

Yin et al. Nature Reviews Neuroscience 7 , 464 – 476 (June 2006) | doi:10.1038/nrn1919

X Tian et al. Nature 000 , 1-4 (2013) doi:10.1038/nature 12234

Drug Discovery &amp; Development

OL Krivanek et al. Nature 514 , 209 - 212 (201 4 ) doi:10.1038/nature 13870

PA Northcott et al. Nature 000 , 1 - 7 (201 4 ) doi:10.1038/nature 13379

PA Northcott et al. Nature 000 , 1 - 7 (201 4 ) doi:10.1038/nature 13379

Martino et al. Nature Reviews Neuroscience 7, 395 – 406 (May 2006) | doi:10.1038/nrn1908

P van Galen et al. Nature 510 , 268 -272 (2014) doi:10.1038/nature 13228

Drug Discovery & Development

Drug Discovery & Development