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Preprocess expression data and select genes

Gene Ontology. Time-Course Gene Expression. Binding Site Sequences. Genome-Wide Location Analysis. Preprocess expression data and select genes. Encode binding site sequences. Determine network motifs for TFs. Preprocess data. Cluster genes using FCM and GO information.

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Preprocess expression data and select genes

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  1. Gene Ontology Time-Course Gene Expression Binding Site Sequences Genome-Wide Location Analysis Preprocess expression data and select genes Encode binding site sequences Determine network motifs for TFs Preprocess data Cluster genes using FCM and GO information Design an SVM Classifier Assign gene clusters to biological functions Assign TFs to known network motifs or predicted by SVM Cluster genes Assign network motifs to TFs Select a TF with assigned network motif Generate candidate gene clusters using GA No Select an RNN structure All TFs tested? No Yes Stopping criteria met? Determine optimal RNN parameters Yes Construct network motifs Hypotheses & validation of inferred regulatory modules

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