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THP1

DNA. HSP90 b. Control. TPA. THP1. LeptoB 5nM. LeptoB +TPA. Control. NaB. HT-29. LeptoB 10nM. LeptoB +NaB. Supplementary figure 2. Leptomycin B blocks HSP90 b cytosolic translocation during cell differentiation.

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THP1

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  1. DNA HSP90b Control TPA THP1 LeptoB 5nM LeptoB +TPA Control NaB HT-29 LeptoB 10nM LeptoB +NaB Supplementary figure 2 Leptomycin B blocks HSP90b cytosolic translocation during cell differentiation Fluorescence microscopy analysis of HSP90b (red) in monocytic THP1 and colon cancer HT-29 cells either left untreated (control) or induced to differentiate by treatment with TPA (20 nM, 24 h) or sodium butyrate (NaB, 3 mM, 48 h) respectively, in the presence or absence of leptomycin B (5 nM for THP1 and 10 nM for HT-29 cells). Nuclei, labelled with Hoescht 33342, are stained in blue.

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