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Hotet från omvärlden ökar. Increased knowledge on an increasing problem number of hits in Pub-MED for (antibiotic or antimicrobial) + resistance by 5 year’s periods. MRSA in Europe 2004. Data from EARSS. The tip of the iceberg….
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Increased knowledge on an increasing problemnumber of hits in Pub-MED for (antibiotic or antimicrobial) + resistance by 5 year’s periods
The tip of the iceberg… • Crude estimate from Israel: 4% of all fatalities in hospitals related to Gram-neg multiresistant nosocomial inf. (Carmeli 2005) • Crude estimate from EU-15: 5,800 excess deaths in ICU related to resistance (Harbarth et al 2005) • Rough estimate of global gonnorhoea treatment failure:3 million cases annually (of total 62 million cases) (Tapsall 2005)
The Current Paradox Antibiotic Resistance Drug Development
Sales of Antibiotics in the Nordic Countries1978-2004 DDD/1000 inhabitants/day
Sveriges beredskap är god? Optimal sjukhusanvändning? Optimal kinolonanvändning? Optimal diagnostik? Optimal hygien? Optimal profylax?
Guidelines does not work unless they are implemented ! Implementation does not work unless there is local comittment and educational outreach !