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DNA Replication Created by Kim Useglia -former student teacher

DNA Replication Created by Kim Useglia -former student teacher. DNA replicates before a cell divides Occurs during the S or synthesis phase of the cell cycle Replication creates identical copies of DNA strands Takes place in the nucleus. Facts:. “Rungs of ladder”. Nitrogenous

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DNA Replication Created by Kim Useglia -former student teacher

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  1. DNA ReplicationCreated by Kim Useglia-former student teacher

  2. DNA replicates before a cell divides Occurs during the S or synthesis phase of the cell cycle Replication creates identical copies of DNA strands Takes place in the nucleus Facts:

  3. “Rungs of ladder” Nitrogenous Base (A,T,G or C) “Legs of ladder” Phosphate & Sugar Backbone DNA Double Helix 3

  4. 3’ Parental DNA Molecule 5’ Replication Fork 3’ 5’ • Begins atOrigin of Replication • Two strands open forming a Replication Forks (Y-shaped region) • New strands grow at the forks Replication:

  5. The Enzyme, Helicase, unwinds and separates the 2 DNA strands by breaking the weak hydrogen bonds • DNA polymerase adds nucleotides complimentary to the parental strand Enzymes

  6. Mutations

  7. Replication occurs at multiple sites along the DNA • DNA polymerase is very accurate • However mutations do occur • Proofreading occurs continuously by DNA polymerase Proofreading

  8. Write the complimentary strand: T A C G G A C T A A C G C More practice

  9. Write the complimentary strand: T A C G G A C T A A C G C A T G C C T G A T T G C G More practice

  10. When and where does DNA replication occur? What is the relationship between adenine and thymine called? What are the two enzymes involved in DNA replication? Review

  11. In pairs you are going to create your own DNA models. Activity

  12. Sugar - Black pentagon • Phosphate - White tube • Nitrogenous bases - • Adenine - Orange (5) • Guanine - Yellow (4) • Cytosine - Blue (4) • Thymine - Green (5) • Hydrogen bonds - White rods Pieces

  13. Create 18 nucleotides Put together a 9 rung ladder of DNA Be sure to have correct base pairing After having a complete DNA molecule create 18 more nucleotides Procedure

  14. Begin to “unzip” DNA molecule from one end Add complimentary nucleotides to create two DNA molecules DNA replication

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