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Station #3: Genetic Toxicology

7. D. N. A. A. d. d. u. c. t. s. (. N. -. G. u. a. n. i. n. e. ). Station #3: Genetic Toxicology. Definitions Genetic Toxicology: A toxicology discipline focused on studying the effect chemicals have on the genome

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Station #3: Genetic Toxicology

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  1. 7 D N A A d d u c t s ( N - G u a n i n e ) Station #3: Genetic Toxicology Definitions Genetic Toxicology:A toxicology discipline focused on studying the effect chemicals have on the genome Mutagen:a chemical shown to cause changes in the genetic sequence of a host Clastogen:a chemical shown to change the normal structure of chromosomes Carcinogen:a compound shown to cause cancer in animals or humans Common Test for Genotoxic Chemicals Gene Mutations:specially designed bacteria or animals cells are exposed to a chemical, if mutations occur, mutant colonies grow can be counted Clastogenicity Tests:expose human or animal cells to a chemical and determine the effect on chromosome structure Why study genetic toxicology?Changes in the normal structure and sequence of DNA can lead to a number of health problems including cancer • Aflatoxin B1 Example: • Aflatoxin B1 is a chemical substance produced from fungi that contaminates a number of crops including nuts, corn, soybean, and cotton. Therefore ingestion by animals and humans can occur; most common among developing nations • Aflatoxin B1 is a potent chemical carcinogen and associated with liver cancer in humans Written by Greg Stevens Created by Michelle Horner

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