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Carboxylic Acid Derivatives

Carboxylic Acid Derivatives. Phosphate Nomenclature. Nucleophilic Substitution Rxn’s. Sterics. Electronics (polarization). Sulfer is more polarizable than oxygen, thus a better leaving group Why acetic anhydride then? Resonance (stabilization of L.G.). Isotope Labeling.

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Carboxylic Acid Derivatives

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  1. Carboxylic Acid Derivatives

  2. Phosphate Nomenclature

  3. Nucleophilic Substitution Rxn’s

  4. Sterics

  5. Electronics (polarization) Sulfer is more polarizable than oxygen, thus a better leaving group Why acetic anhydride then? Resonance (stabilization of L.G.)

  6. Isotope Labeling • How do we really know how these mechanisms work?

  7. DCC most commonly used for the synthesis of peptides (proteins)

  8. LAH reduction forms an alcohol Aluminum plays an important role in the mechanism

  9. Sterics Role in Alcoholysis

  10. Grignard attack of Acid Chlorides Will get two additions, can’t control single vs. double addition

  11. Gilman Reagent – Can Isolate the Ketone Example:

  12. Synthesis of Aspirin

  13. Preparation of Tylenol

  14. Interesting Ester Examples

  15. Ester Synthesis

  16. Base Catalyzed Hydrolysis

  17. Acid Catalyzed Hydrolysis

  18. Synthesis of Amides

  19. Base Catalyzed Hydrolysis

  20. What should you expect in Biochemistry?

  21. LAH reduction of Amides

  22. Step Growth Polymers

  23. Biodegradable Polymers

  24. NMR of Ethyl Acetate

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