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Sea lamprey VDR

? Other ligands. Sea lamprey VDR. 1,25-(OH) 2 -vitamin D 3 (high affinity). Lithocholic acid (low affinity); ability to upregulate CYP3A expression. Human VDR. Mouse VDR. ? Role in zebrafish development. Zebrafish PXR. Strong activation by benzoates (developmental role);

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Sea lamprey VDR

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  1. ? Other ligands Sea lamprey VDR 1,25-(OH)2-vitamin D3 (high affinity) Lithocholic acid (low affinity); ability to upregulate CYP3A expression Human VDR Mouse VDR ? Role in zebrafish development Zebrafish PXR Strong activation by benzoates (developmental role); altered tissue distribution from other PXRs loss of activation by steroids and bile salts BXRa (Xenopus laevis) Single ancestral gene BXRb (Xenopus laevis) Androstane and pregnane steroids, C27 bile alcohol sulfates; ability to upregulate CYP3A expression Chicken PXR High constitutive activity CARs (duplication of pre-mammalian PXR) C24 bile acids; broader specificity for steroids and xenobiotics Rabbit PXR Mouse PXR Rat PXR Broadest ligand specificity Dog, pig, rhesus PXRs Human PXR

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