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The Neurology of Speech and Language: Avians to Humans

The Neurology of Speech and Language: Avians to Humans. David B. Rosenfield, M.D. Director, Speech/Language Center Director, EMG/Motor Control Lab. Professor of Neurology Weill Cornell Medical College. Times are Changing for Modeling Language and Speech. Brain imaging Analysis of sounds

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The Neurology of Speech and Language: Avians to Humans

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  1. The Neurology of Speech and Language: Avians to Humans David B. Rosenfield, M.D. Director, Speech/Language Center Director, EMG/Motor Control Lab. Professor of Neurology Weill Cornell Medical College

  2. Times are Changing for Modeling Language and Speech Brain imaging Analysis of sounds Spectral and temporal analysis Phonemes Morphemes Syllables Phrases New approaches in modeling

  3. Language • Representational System • Generativity • Drives the motor system

  4. Speech Motor Control System • Respiratory • Articulatory • Phonatory (e.g., laryngeal)

  5. Mammalian Vocalization Involves Coordination of: • Respiration - anterior horn cells (cerrvical, thoracic, upper lumbar) • Laryngeal activity - neurons controlling glottic closure (n. ambiguous) • Articulatory mechanism (supralaryngeal) • V Motor n. • VII n. • Rostal n. ambiguous • XI n. • Upper cervical anterior horn cells

  6. Neuroanatomy of Language • Two principal regions for language • Sup. temporal areas adjacent to auditory cortex • Inferior frontal cortex adjacent to articulatory motor cortex • These two regions connected by several white matter tracts • Extreme capsule • Uncinate fasciculus • Arcuate fasciculus (well developed in humans)

  7. Areas of Language Function • Pars Triangularis (PTR, #45) • Heteromodal cortex • Located within inferior frontal gyrus • Pars Opercularis (POP, #44) • Motor Association Cortex • Planum Temporale (PT, #22) • Auditory Association Cortex

  8. Broca’s and Wernicke’s Area • No cytoarchitectonic signature • Cannot identify by looking under a microscope • Broca’s Area • Portions of #44 and of #45 • Wernicke’s Area • Portion of #22

  9. Broca’s and Wernicke’s Area • External brain stimulations: • While talking > cease talking • While not talking > grunt from Broca’s, nothing from Wernicke’s • Anatomy BA and WA • Connections are polysnaptic • Connections are bi-directional • No direct connections to n. ambiguous • None below periaqueductal gray

  10. Non-human Primates v. Humans Language v. Communication Systems We learn tens of thousands of words/symbols; NHP <40 signs Humans learn syntax, gen. grammar Anatomic differences: Association cortex More fronto-temporal connections

  11. 60-65d Critical period closes Sensory learning Sensorymotor 90d Crystallization 25-40d Singing begins Song Learning in Zebra Finches J. neurosci, February 1, 1997 17(3):1147-1167

  12. Parasagittal Section of Male Zebra Finch Brain HVC LMAN LMAN Area X RA RA DLM DLM

  13. Learning song Maintaining song HVC FIELD L N I F LMAN X RA DLM N XII ts DM Ts nerve to trachea and syrinx

  14. Comparison between ZF Birdsong and Human Speech Birdsong Human Speech Occurs early in life ++++ ++++ Dependent on auditory feedback ++++ ++++ Dependent on specialized brain areas ++++ ++++ Spectrally complex ++++ ++++ Temporally complex ++++ ++++ Hierarchically controlled ++++ ++++ Modular* ++++ ++++ * (E.g., notes, syllables, phrases, phonemes, words, sentences, paragraphs)

  15. “Domestic”

  16. Normal Song 1

  17. Normal Song 2

  18. Repeater Song 1

  19. Repeater Song 2

  20. Rauschecker and Scott, Nature Neuroscience, 2009

  21. Improved Understanding of Our Knowledge of Language and Speech Anatomy Imaging Physiology Greater attention in new clinical domains stuttering dysphonia aphasia rehabilitation

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