1 / 8

INTRODUCTION TO AUTONOMIC PHARMACOLOGY: Part IV Adrenergic and cholinergic receptors

INTRODUCTION TO AUTONOMIC PHARMACOLOGY: Part IV Adrenergic and cholinergic receptors. Adrenergic Receptors: Receptors Activated by EPI/NE.  -adrenergic receptors (Epinephrine>Isoproterenol).  -adrenergic receptors (Isoproterenol>Epinephrine). a.  1 -adrenergic receptors (EPI = NE).

frayne
Download Presentation

INTRODUCTION TO AUTONOMIC PHARMACOLOGY: Part IV Adrenergic and cholinergic receptors

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. INTRODUCTION TO AUTONOMIC PHARMACOLOGY: Part IV Adrenergic and cholinergic receptors

  2. Adrenergic Receptors: Receptors Activated by EPI/NE -adrenergic receptors (Epinephrine>Isoproterenol) -adrenergic receptors (Isoproterenol>Epinephrine) a  1-adrenergic receptors (EPI = NE) 1-adrenergic receptors (Phenylephrine>Clonidine)  2-adrenergic receptors (EPI>NE) 2-adrenergic receptors (Clonidine>Phenylephrine)  3-adrenergic receptors (NE>EPI)

  3. Adrenergic Receptors: Signal Transduction

  4. Signal Transduction by 1 - Adrenergic Receptors Gq q q

  5. Signal Transduction by 2 - and  - Adrenergic Receptors

  6. Cholinergic Receptors: Receptors Activated by Ach Muscarinic Receptors (Activated by muscarine from Amanita muscaria) Nicotinic Receptors (Activated by nicotine from tobacco) M1 (Nerve Cells) (Defined by Molecular Cloning) M2 (Heart & SM) NM (Neuromuscular) M3 (Heart & SM) (Blocked by Tubocurarine) NN Autonomic ganglia, Adrenal medulla & CNS M4 (SM & Glands) M5 (?) (Blocked by Trimethaphan)

  7. Cholinergic Receptors: Signal Transduction

  8. Muscarinic Receptors Gq Activation of PLC Gi Formation of IP3 Formation of DAG  subunit  subunit Release of Intracellular Calcium Activation of PKC Inhibition of Adenylyl Cyclase Opening of Potassium Channels

More Related