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Featured Article :. Personalized Management of Hyperglycemia in Type 2 Diabetes: Reflections from a Diabetes Care Editors’ Expert Forum. Itamar Raz, M.D., Matthew C. Riddle, M.D., Julio Rosenstock, M.D.,

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Featured Article :

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  1. Featured Article: Personalized Management of Hyperglycemia in Type 2 Diabetes: Reflections from a Diabetes Care Editors’ Expert Forum. Itamar Raz, M.D., Matthew C. Riddle, M.D., Julio Rosenstock, M.D., John B. Buse, M.D., Ph.D., Silvio E. Inzucchi, M.D., Philip D. Home, D.M., D.P.H.I.L., Stefano Del Prato, M.D., Ele Ferrannini, M.D., Juliana C.N. Chan, M.D., Lawrence A. Leiter, M.D., Derek LeRoith, M.D., Ph.D., Ralph DeFronozo, M.D., William T. Cefalu, M.D. Diabetes Care Volume 36: 1779-1788 June, 2013

  2. PRACTICAL APPROACHES TO PERSONALIZED MEDICINE • In June 2012, 13 leaders convened in a Diabetes Care Editors’ Expert Forum to discuss the concept of personalized medicine in the wake of a recently published American Diabetes Association/European Association for the Study of Diabetes position statement • Position statement calls for a patient-centered approach to hyperglycemia management in type 2 diabetes Raz I. et al. Diabetes Care 2013;36:1779-1788

  3. Raz I. et al. Diabetes Care 2013;36:1779-1788

  4. STATE OF THE ART FOR PERSONALIZING MEDICINE • Personalized medicine can be defined in different ways: • • Shared decision-making approach that takes patient preferences and values into account when developing a management plan • • Identifying a particular set of phenotypic and genotypic markers that would define ideal and nonideal therapies for individuals based on evidence rather than on clinical impressions Raz I. et al. Diabetes Care 2013;36:1779-1788

  5. Raz I. et al. Diabetes Care 2013;36:1779-1788

  6. ARE ADEQUATE THERAPEUTIC TOOLS AVAILABLE NOW FOR PERSONALIZED DIABETES CARE? • Pharmacological agents for hyperglycemia management should aid clinicians in providing early treatment to delay or prevent complications • Trial evidence is limited for the optimal use of these agents, especially in dual or triple combinations • In the future, genotyping and testing for metabolomic markers may help us to better phenotype patients and predict their responses to antihyperglycemic drugs • For now, a personalized (“n of 1”) approach in which drugs are tested in a trial-and-error manner in each patient may be the most practical strategy for achieving therapeutic targets Raz I. et al. Diabetes Care 2013;36:1779-1788

  7. REGIONAL PERSPECTIVES ON PERSONALIZED MEDICINE • The viewpoint that personalized diabetes care may be too complex to be implemented in many care settings is common in Europe, as it is in the United States and elsewhere Raz I. et al. Diabetes Care 2013;36:1779-1788

  8. ENHANCING PERSONALIZED CARE THROUGH COMANAGEMENT • There is strong evidence in favor of standardized treatment goals and an algorithmic initial therapy pathway involving lifestyle modification, metformin, and the addition of other oral agents • This approach allows newly diagnosed patients to attain a reasonable blood glucose range and to maintain it for some time • Personalizing diabetes care will require improved cooperation and comanagement of patients among HCPs in various disciplines Raz I. et al. Diabetes Care 2013;36:1779-1788

  9. CONCLUSIONS • Patient-centered care and standardized algorithmic management are conflicting approaches • These approaches can be made more compatible by recognizing instances in which personalized A1C targets are warranted and clinical circumstances that may call for comanagement by primary care and specialty clinicians Raz I. et al. Diabetes Care 2013;36:1779-1788

  10. Raz I. et al. Diabetes Care 2013;36:1779-1788

  11. Raz I. et al. Diabetes Care 2013;36:1779-1788

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