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IDO 2008

IDO 2008. Dengue Ontology, User-Developer perspective. Overview. Biology Current system A decision support system as a solution What is Dengue? Really, what is Dengue? The DDSS Control Vocabulary Dengue Ontology. Disease and Mosquito Cycle. 1 Main mosquito vector

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IDO 2008

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  1. IDO 2008 Dengue Ontology, User-Developer perspective

  2. Overview Biology • Current system • A decision support system as a solution • What is Dengue? • Really, what is Dengue? • The DDSS • Control Vocabulary • Dengue Ontology

  3. Disease and Mosquito Cycle 1 Main mosquito vector 1 Main disease target 3 Disease manifestations 4 Virus serotypes 9 Day from egg to adult* 14 day to become infectious* * Temperature dependent http://www.entm.purdue.edu/publichealth/images/downloads/lifecycle-mosquito.jpg

  4. Merida 500 000 (estimated) DHF cases require hospitalization each year 2.5% of those affected die 2.5 billion people at risk http://en.wikipedia.org/wiki/Dengue http://www.who.int/mediacentre/factsheets/fs117/en/

  5. Urban Area of Merida Because of the interaction of three semi-independent components the vector borne disease behave differently from communicable diseases. Total cases in 2007 Merida

  6. Potential for rapid outbreak response based on clinical syndromic surveillance

  7. What is Dengue? • Disambiguation • Dengue Virus is_a Pathogen • Dengue Fever is_a Disease • Dengue Fever is_a Diagnosis • Dengue Fever Clasic is_a Manifestation • Dengue Case instance_of Dengue Fever?

  8. What is Dengue? • WHO • Dengue fever and dengue hemorrhagic fever (DHF) are acute febrile diseases, found in the tropics and Africa, and caused by four closely related virus serotypes of the genus Flavivirus, family Flaviviridae. • (Some) Health Departments • What WHO Says but, it is not Dengue until it was been confirmed by the laboratory.

  9. What is Dengue? • Most dengue cases are usually clinically diagnose • No Pathognomonic symptom • The list includes more than 50 • They can drastically vary by subject and by outbreak. • There are 3 WHO recognized diagnosis (manifestations)‏ • Dengue Fever a.k.a Classic Dengue • Dengue Hemorrhagic Fever (Thrombocytopenia <1x 105 platelets/mm³ • Dengue Shock syndrome • Dengue Fever with hemorrhagic manifestations

  10. What is Dengue? • What is Diagnosis? • What is Disease? Disease Ontology WorkshopThe Ontology of Diagnosis(to be quoted as work in progress)Baltimore, MD, USA. November 7, 2006

  11. instance-of at t1 Pedro Juarez DHF was diagnosed by PCR inst-of at t2 Person Juan Perez Dengue was diagnosed by PCR instance-of at t1 inst-of at t2 Disease inst-of at t2 instance-of at t1 Diagnosing inst-of at t2 instance-of at t1 method

  12. instance-of at t1 Juan Perez Dengue was diagnosed by PCR depend_on depend_on Person Dengue Fever Dengue Virus caused_by Symptoms Pedro Juarez DHF was diagnosed by PCR Person inst-of at t2 Disease Diagnosing method

  13. has_part Person depens_on Head has_part Symptoms gum instance-of at t instance-of at t Juan’s headache has_location Juan’s head Juan’s mialgya has_location Juan’s muscles Juan’s bleedinggums has_location Juan’s gums

  14. A well-formed diagnosis of dengue? Disease is_a? Dengue Fever instance-of at t caused_by Juan’s portionof viruses Juan’s Dengue

  15. A well-formed diagnosis of dengue? Disease is_a instance-of at t caused_by Juan’s Dengue Dengue virus Dengue Fever Realization_of AsymptomaticDengue Fever Dengue Fever Hem. Manif. Dengue Fever Hemorrhagic Dengue Fever Shock syndrome Dengue has_symptom is_a has_symptom Headache Epistaxis Diagnosis

  16. instance-of at t1 Pedro Juarez DHF was found in 12 Northstreet #123 Person inst-of at t2 Juan Perez Dengue was found in 320 Southstreet #456 instance-of at t1 inst-of at t2 Disease instance-of at t1 inst-of at t2 Finding instance-of at t1 inst-of at t2 Place

  17. Disease is_a instance-of at t caused_by Juan’s Dengue Dengue virus Dengue Fever located_in 320 Southstreet #456 instance-of at t Premise located_in Block MX1235 instance-of at t Block located_in Merida instance-of at t Populated place

  18. Problems of using English • Street Ni▄os Caj¬¯n and Ninos Cajon and Nignos Cajon are not Niños Cajón • Add all the characters of all the lenguajes • Is not just annotation. Wrong characters renders the terms useless. • Jorgue Guachintón located_in Guayomin located_inYunited Estates is not George Washington….

  19. instance-of at t1 Pedro Juarez DHF was diagnosed by symptoms .. Person inst-of at t2 Juan Perez Dengue was diagnosed by symptoms … instance-of at t1 inst-of at t2 Disease instance-of at t1 inst-of at t2 Diagnosing instance-of at t1 inst-of at t2 symptoms

  20. A well-formed diagnosis of dengue? Juan’s Dengue instance-of at tx Low bloodpressure Epistaxis Headacheonset has_symptom has_symptom AsymptomaticDengue Fever Dengue Fever Hem. Manif. Dengue Fever Hemorrhagic Dengue Fever Shock syndrome Dengue t Juan goes to the doctor Juan is hospitalized

  21. DDSS (1): System flow scheme Functional definition of Decision Support System:An interactive and adaptable system that aids the process of gathering and analyzing information, gaining new insights, generating alternatives, and making decisions

  22. DDSS (2): Essential DDSS characteristics • Integrates into existing vector/dengue control programs at local/regional levels (single DDSS) or national levels (DDSS network). • DDSS application packages will be made accessible in English and Spanish language versions. • Self-application concept provides potential for rapid world-wide implementation. • Flexible DDSS implementation to fit a wide range of resource environments. • Minimum capital investment for implementation of a basic DDSS is estimated at $1,500 per location (low-end computer, basic GPS unit and software). • User-friendly; designed for use by regular vector control personnel. • Standardized data entry formats to facilitate compilation of data from multiple locally operated DDSS for national level analysis.

  23. DDSS (3)

  24. DDSS (5)

  25. Disease and Vector control/surveillance activities Case Reports • Control Activities • ULV Insecticide spray • Immature Control • Breeding site control • Control Activities(Reactive) Infected Count -- • Surveillance • Counts and ndexes • Breeding Sites • Control Activities(Reactive) - Case Reports http://www.entm.purdue.edu/publichealth/images/downloads/lifecycle-mosquito.jpg

  26. DDSS (7):Selected outputs from DDSS-1 • Documentation to support operational logistics: • - Workload and cost related to different program activities. • - Spatial coverage of surveillance and control activities. • - Insecticide types and quantities used. • Entomological data display outputs showing: - Seasonal and spatial patterns of vector abundance. - Contribution of different container types to vector production. - Effect of implemented control strategies on vector abundance. • Epidemiological data display outputs showing: • - Distribution of DF and DHF cases by sex and age group. • - Seasonal and spatial patterns of occurrence of DF and DHF cases. • - Seasonal and spatial patterns ofDF and DHF incidence (if population census • data are available). • - Effect of implemented vector control strategies on DF and DHF incidence • (based on passively collected data). • Priority Area classification for vector control. • GIS-backbone to support vector/dengue control (and build public health capacity).

  27. DDSS (8): Expected outcomes from DDSS-1 • Evidence-based decision making and use of locally appropriate vector/dengue control program strategies and methodologies. • Improved capacity for data entry, storage, retrieval, analysis and display. • Better use of available resources through improved understanding of the relative costs and benefits of different surveillance and control approaches. • Better targeting of limited resources for vector control to high risk areas. • Improved capacity for effective emergency vector control response through more rapid flow of information between public health institutions and vector/dengue control programs.

  28. DDSS (4): Evolution of DDSS system design Past Present Future 2–tier system (GUI – Database) 2–tier system (GUI – Database) 3–tier system (GUI – Business Logic - Database) GUI: MS Visual Basic Database: Access or SQL Server Express GUI: MS Visual Basic Database: PostgreSQL with PostGIS extension VB-Java Java PostgreSQL with PostGIS extension

  29. DDSS (5): Use of open source software Google Earth PostgreSQL Reporting R Stats Pack ZedGraph PlottingLibrary

  30. Thank you

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