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Polymeric Frameworks for Membrane-active Antimicrobial Agents Kenichi Kuroda, University of Michigan Ann Arbor, DMR 0845592. +. +. +. +. +. +. +. +. +. +. +. +. +. +. +. +.

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  1. Polymeric Frameworks for Membrane-active Antimicrobial AgentsKenichi Kuroda, University of Michigan Ann Arbor, DMR 0845592 + + + + + + + + + + + + + + + + Due to the emergence of antibiotic-resistant bacteria, we need new antimicrobial strategies. Our strategy is to utilize polymeric and macromolecular frameworks to create membrane-active agents that can mimic host-defense peptides. We demonstrated that cationic amphiphilic polymethacrylates display a broad spectrum of activity, selective toxicity to bacteria over human cells, and limited development of resistance in bacteria, which are hallmarks of host-defense peptides. Our approach will provide a new strategy to create cost-effective, stable, and versatile antimicrobial agents, which can be used to combat antibiotic-resistant bacteria. S. aureus E. coli Above: Antimicrobial polymers (R= alkyls) and membrane disruption. Below: Fluorescence microscopy images of E. coli and S. aureus incubated with dye-labeled polymers (green fluorescence). The polymers permeabilized the cell membranes and entered the cells. (Collaboration with Prof. Xi at Public Health in University of Michigan) 5µm

  2. Polymeric Frameworks for Membrane-active Antimicrobial AgentsKenichi Kuroda, University of Michigan Ann Arbor, DMR 0845592 Na+ Na+ Na+ Na+ Na+ Ca2+ Ca2+ Alginate Gummy Worms: cross-linking alginate polymers by calcium ions Na+ Ca2+ Na+ Special Summer Enrichment Program, Chemistry & IDEA Institute, University of Michigan(Program Manager: Dr. Mary Starr) This program was offered to high school students currently attending various high schools throughout Southeast Michigan, including Cass Technical High School in Detroit, MI. Twenty four students participated in this program and learned basic concepts and theory behind chemical phenomena. My graduate student, Ms. Laura Thoma, and I gave a lecture with scientific demonstration on alginate hydrogels, thickening additives in the food industry. This hands-on experience helped the high school students to link their knowledge to actual uses of chemical reactions in our life. Na+ Ca2+ Na+ Na+ Na+ COO- Alginate solution with different food colors CaCl2 solution

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