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p22 phox

cit C. Stimuli inducing increased mitochondrial generation of ROS: serum deprivation - hypoxia integrin signalling - ceramide apoptosis - p53 TNF  - oncogenic Ras. I. III. II. IV. UQ UQ-H 2. ● -. ● -. 2O 2. 2O 2. mt SOD. ●-. O 2.

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p22 phox

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  1. cit C • Stimuli inducing increased mitochondrial generation of ROS: • serum deprivation - hypoxia • integrin signalling - ceramide • apoptosis - p53 • TNF - oncogenic Ras I III II IV UQ UQ-H2 ●- ●- 2O2 2O2 mt SOD ●- O2 H2O2 ●- 2O2 2O2 2O2 gp91 phox p22 phox p47 phox p40 phox Nox Family p22 phox ( ( ( H2O2 p67 phox Rac p47 phox + + p40 phox p67 phox + + NADP + H NADP + H ( NADPH Nox A1 Rac NADPH 5-lipoxygenase 2 AA+O2 Rac 2 HPETE H2O2 cSOD a) Mitochondria b)NADPH oxidase Non-Phagocytic Cells Phagocytic Cells H2O2 Stimuli for activation of NADPH oxidase and 5-lipooxygenase c) 5-lipoxygenase

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