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Dr. Peter J.E. Verdegem Chief Scientific Officer

Dr. Peter J.E. Verdegem Chief Scientific Officer. VisuTein: A powerful protection for age-related eye disorders. The human eye: anatomy. Cataract. Scene with normal vision. Scene with cataract vision. Pictures: NEI. Glaucoma. Scene with normal vision. Scene with glaucoma vision.

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Dr. Peter J.E. Verdegem Chief Scientific Officer

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  1. Dr. Peter J.E. Verdegem Chief Scientific Officer

  2. VisuTein: A powerful protection for age-related eye disorders

  3. The human eye: anatomy

  4. Cataract Scene with normal vision Scene with cataract vision Pictures: NEI

  5. Glaucoma Scene with normal vision Scene with glaucoma vision Pictures: NEI

  6. Age-related Macula Degeneration Scene with normal vision Scene with AMD vision Pictures: NEI

  7. AMD & Amsler grid Normal AMD

  8. Prevention Eye diseases: current treatments • Cataract • Lens extraction • AMD • Laser surgery • Glaucoma • Drug therapy • Laser surgery • Conventional surgery

  9. O2•– H2O2 GSH peroxidase SOD Catalase Removal damaged proteins Sun light OH• Proteases Oxidized Proteins Protein Accumulation of damaged proteins Disfunctional Proteases Vitamin E, C Beta-carotene Cataract Cataracts: biological background

  10. Vitamin C Vitamin E I Beta carotene Module 1 Direct antioxidants

  11. 1,8 1,6 1,4 1,2 1 0,8 0,6 0,4 0,2 0 Antioxidants: Studies for Cataract Multivitamins Vitamin C Vitamin E Jacques, PF; Int. J. Vitam. Nutr. Res. 1999; 69:198.

  12. Vitamin C Vitamin B6 Vitamin E I N-acetyl-L-cystein Mixed carotenoids Selenium Zinc Copper Module 1 Direct antioxidants Glutathion synthesis stimulation Co-factors for enzymatic antioxidant defence Herbal antioxidant source Vaccinium myrtillus

  13. Herbal antioxidants • Rich in anthocyanosides • Stimulant of visual acuity Morazzoni, P et al; Fitoterapia 1999; 67:3.

  14. I Module 2 Vitamin A Important nutrients Beta carotene

  15. III Lutein Zeaxanthin Module 3 Macula pigments

  16. Macular pigment: lutein and zeaxanthin • Function • Structural • UV-protection Lutein • Source • Dark green leafy • vegetables Zeaxanthin

  17. 14 2,5 12 2 10 8 1,5 6 4 1 2 0 0,5 -2 -4 0 -15 -10 -5 0 5 10 15 Dist from centre (mm) Macular pigment: lutein and zeaxanthin Lutein Zeaxanthin Landrum; Arch. Bioch. Biophys. (2001); 385:28.

  18. Lutein supplementation Landrum, J et al; Am. J. Clin. Nutr. 2000; 72:844.

  19. Clinical Study with VisuTEIN • Louisiana Retinal Institute • Dry AMD patients • Study versus OcuVite • Improvements • Recovery from a flash • Contrast sensitivity • Visual Acuity

  20. Dr. Peter J.E. Verdegem Chief Scientific Officer

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