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CHAPTER 13

CHAPTER 13. Red Blood Cell & Bleeding Disorders. RBC and Bleeding Disorders. NORMAL PATHOLOGY. NORMAL. Development of Blood Cells RBC WBC Platelets Anatomy of Bone Marrow. PATHOLOGY. ANEMIAS POLYCYTHEMIA BLEEDING DISORDERS. ANEMIAS. BLOOD LOSS INCREASED DESTRUCTION (HEMOLYTIC)

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CHAPTER 13

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  1. CHAPTER 13 Red Blood Cell&Bleeding Disorders

  2. RBC and Bleeding Disorders • NORMAL • PATHOLOGY

  3. NORMAL • Development of Blood Cells • RBC • WBC • Platelets • Anatomy of Bone Marrow

  4. PATHOLOGY • ANEMIAS • POLYCYTHEMIA • BLEEDING DISORDERS

  5. ANEMIAS • BLOOD LOSS • INCREASED DESTRUCTION (HEMOLYTIC) • DECREASED PRODUCTION

  6. Anemias of Blood Loss • Acute • Chronic

  7. Hemolytic Anemias:IN-creased Destruction • Spherocytosis • Glucose-6-Phosphate Dehydrogenase Deficiency • Hemoglobin S • Thalassemias • Hemoglobin H • PNH (Paroxysmal Nocturnal Hemoglobinuria) • Autoimmune Anemias: Warm, Cold Ab’s • Red Cell Trauma

  8. Hereditary Spherocytosis • Molecular Pathology • Morphology • Clinical Course

  9. G6PDDeficiency

  10. Hemoglobin S (Sickle Cell) • Pathogenesis • Morphology • Clinical Course

  11. Thalassemias • Beta-Thalassemias • Major • Minor • Alpha-Thalassemias • Silent Carrier • Trait

  12. Hemoglobin H

  13. Paroxysmal Nocturnal Hemoglobinuria (PNH)

  14. ImmunohemolyticAnemias • Warm Antibody • Cold Agglutinin • Cold Hemolysin

  15. Hemolysis due toRBC Trauma

  16. Hemolytic Anemias:DE-creased Production • “Megaloblastic” Anemias • B12 Deficiency (Pernicious Anemia) • Folate Deficiency • Iron Deficiency • Anemia of Chronic Disease • Aplastic Anemia • “Pure” Red Cell Aplasia • OTHER forms of Marrow Failure

  17. MEGALOBLASTICAnemias

  18. B12 DeficiencyPernicious Anemia • Normal B12 Metabolism • Etiology of B12 Deficiency • Incidence • Pathogenesis • Morphology • Clinical Course

  19. Anemia ofFolate Deficiency

  20. Fe Deficiency Anemia • Iron Metabolism • Etiology • Morphology

  21. Anemia ofCHRONIC DISEASE

  22. Aplastic Anemias • Etiology • Pathogenesis • Morphology • Clinical Course

  23. “Pure” Red Cell Aplasia

  24. OTHER Forms ofMarrow Failure

  25. Polycythemia • Hypoxic • Polycythemia Vera

  26. Bleeding Disordersaka, Hemorrhagic Diatheses • Vessel Wall Abnormalities • Reduced Platelets • Defective Platelet Function • Abnormal Clotting Factors • DIC (Disseminated Intravascular Coagulation)

  27. Vessel WallAbnormalities

  28. THROMBOCYTOPENIA • ITP (Idiopathic Thrombocytepenic Purpura) • Acute Immune Thrombocytopenia • DRUG-Induced Thrombocytopenia • HIV Associated Thrombocytopenia • Thrombotic Microangiopathies (TTP and Hemolytic Uremic Syndrome)

  29. ITP • Pathogenesis • Morphology • Clinical Features

  30. ACUTE ITP

  31. DRUG InducedThrombocytopenia • HEPARIN

  32. HIV Thrombocytopenia

  33. Thrombotic Microangiopathies • TTP (Thrombotic Thrombocytopenic Purpura) • HUS (Hemolytic-Uremic Syndrome)

  34. Defective Platelet Functions

  35. Abnormal Clotting Factors • Factor-VIII-vWF (Von Willebrand Disease) • Hemophilia A (VIII Deficiency) • Hemophilia B (IX Deficiency, aka “Christmas” Disease)

  36. Von Willebrand Disease

  37. Hemophilia A (VIII)

  38. Hemophilia B (IX)

  39. DIC • Etiology • Pathogenesis • Morphology • Clinical Course

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