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From Behaviour to Brain to Gene … and back again

Presented by Richard Hill MA www.richardhill.com.au. From Behaviour to Brain to Gene … and back again. a woman without her man is nothing. A woman, without her man, is nothing. A woman: without her, man is nothing. Gene expression Epigenetic silencing.

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From Behaviour to Brain to Gene … and back again

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  1. Presented by Richard Hill MA www.richardhill.com.au From Behaviour to Brain to Gene … and back again

  2. a woman without her man is nothing A woman, without her man, is nothing. A woman: without her, man is nothing.

  3. Gene expressionEpigenetic silencing • State dependent gene expression • Activity dependent gene expression • Epigenetic marking – methylation, acetylation. Access of transcription factors to promoter region. • Nucleosome tension – ionic tightness.

  4. Becoming Human

  5. Psychosocial Genomics The deep psychobiological process of “activity or experience-dependent gene expression and brain plasticity” associated with creativity and psychotherapy.

  6. Self Organising Systems Initial Conditions – DNA, polymorphisms Organising Principles

  7. Self Organising Systems Optimal • Immune system • Associative brain • Positive emotions • Seeking • Social brain • Adaptation • Dis-integration • Hierarchy of needs • Habituation • Automation / normalisation

  8. Activity 1

  9. How We Remember

  10. Mind – Body Memory Muscles Fascia Connected systems Brain Skin Immune System Organs

  11. Implicit Expression

  12. 9 Voices

  13. Activity 2

  14. EMBODY the UNTRUE TRUTH

  15. ARGUE the UNTRUE TRUTH

  16. The Interplay

  17. The Interplay

  18. The Interplay MIND Brain Autonomic System Immune system Endocrine System Neuropeptides peptides CNS (spinal) Vagus nerve BODY

  19. C.O.A.T. Curiosity Oriented Approach To…

  20. The Purpose of Life To creatively participate in the experience

  21. www.richardhill.com.au richhill@iinet.net.au

  22. A wonderful worm! Caenorhabditis elegans

  23. Stage One: Initiation & Creative Expectation Rossi Stage Two: Incubation, Access Current Experience BREAKOUT Stage Three: Illumination, Aha! Constructing Future Mind Stage Four: Evaluation, Planning, & Reality Testing

  24. Threats • External physical – direct survival • Attachment – abandonement, support survival • Internal physical - Chronic Inflammation – illness, toxicity (principal indicator – obesity)

  25. Ultradian Rhythms

  26. Meaning Making Meaning responsive

  27. Winner/Loser Mindset Living in a competitive, “winner/loser” world where personal worth is based on external measures rather than personal measures. This creates a “winner/loser mindset.” Stress, anxiety, disengagement, distrust, and unhappiness are expected and predictable outcomes of thinking in such a way and living in such a world. Intrinsic – extrinsic motivation. Self-determination Theory – Ryan & Deci

  28. Gene Expression Studies Tickling rat Positive emotion-specific changes in the gene expression profile of tickled rats Hoi, Hayashi, Nakagawa, Sakamoto, Urayama & Murakami Molecular Medicine Reports 2: 157-161, 2009 Music Appreciation and Attachment Musical Aptitude Is Associated with AVPR1A-Haplotypes Ukkola , Onkamo , Raijas , Karma , Jarvela (2009 PLoS ONE 4(5): e5534. doi:10.1371/journal.pone.0005534 • Hypnosis A Pilot Study of Positive Expectations and Focused Attention via a New Protocol for Optimizing Therapeutic Hypnosis and Psychotherapy Assessed with DNA Microarrays: The Creative Psychosocial Genomic Healing Experience  Rossi,Iannotti, Cozzolino, Castiglione, Cicatelli, Rossi The International Journal of Sleep, Dreams and Hypnosis Vol 10, No.2, 2008

  29. Inclinations and Alterations • 5HTT – long/short • COMT – val / meth SNP • MAO-A - repeat • CR hippocampus - methylation • Opioid R amygdala • FoxB nucleus accumbens

  30. Gene Expression Studies BDNF Endogenous BDNF regulates induction of intrinsic neuronal growth programs in injured sensory neurons Geremia1, Lina, Pettersson, Hasmatali, Hryciw1, Danielsen, Schreyer1 & Verge Experimental Neurology July 29, 2009 Article in Press Post 911 Gene Expression Patterns Associated with Posttraumatic Stress Disorder Following Exposure to the World Trade Center Attacks Yehuda, Cai, Golier, Sarapas, Galea, Ising, Rein, Schmeidler, Müller-Myhsok, Holsboer & Buxbaum Biological Psychiatry 2009 April 24 Article in Press Zif268 Ribeiro, Mello, Vehlo, Gardner, Jarvis, & Pavlides, (2002) Induction of hippocampal long-term potentiation during waking leads to increased extra hippocampal zif-268 expression during ensuing rapid-eye-movement sleep. Journal of Neuroscience, 22 (24): 10914-10923.

  31. Therapeutic Brain Plasticity

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