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Lecture 11

Lecture 11. Lipid transport. Fatty. acid. Sources of Cholesterol in Humans. Endogenous Exogenous (diet) Synthesis in Liver Packaged in liver. Cholesterol. Cholesterol esters. Triacylglycerols. Apoproteins. Lipoproteins. Cholesterol transport. Bile salts. Chylomicron.

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Lecture 11

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  1. Lecture 11 Lipid transport

  2. Fatty acid Sources of Cholesterol in Humans Endogenous Exogenous (diet) Synthesis in Liver Packaged in liver Cholesterol Cholesterol esters Triacylglycerols Apoproteins Lipoproteins

  3. Cholesterol transport

  4. Bile salts

  5. Chylomicron

  6. Cholesterol transport Lipoprotein transport system Esterified sterol with a long chain fatty acid (Liver)

  7. Human Plasma Lipoproteins LDL: “Bad” cholesterol HDL: “Good” cholesterol Each type of lipoprotein has a different complement of proteins associated with it

  8. Apolipoproteins

  9. LDL (Low-Density Lipoprotein) • Uptake: very high affinity • ~10-8 M apoB • Uptake: very specific Surface receptor for LDL

  10. Receptor-Mediated Endocytosis of LDL Brown and Goldstein Nobel 1985

  11. Fate of LDL After Endocytosis

  12. Long term regulation

  13. LDL Uptake in FH • Inject radiolabeled LDL • Follow disappearance from blood • FH patients are defective in LDL uptake M.S. Brown and J.L. Goldstein, Science232, 34 (1986)

  14. Defect in FH: LDL Receptor • Mutations reduce affinity for LDL (apoB) • Result: • [LDL] in blood rises • Endogenous cholesterol synthesis goes unregulated M.S. Brown and J.L. Goldstein, Science232, 34 (1986)

  15. Treatment of FH

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