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AIDS 2010: Track B (Clinical Science) Highlights

AIDS 2010: Track B (Clinical Science) Highlights. Dr. Andrew Kambugu, Uganda (Lead) Jain Vivek, USA Dr. Gabriel Chamie, USA Dr. Sabrina Kitaka-Bakera, Uganda Dr. Jose Arribas, Spain Dr. N. Kumarasamy, India Dr. Annie Luetkemeyer, USA Dr. Ted Ruel UCSF, USA. Track B Stats.

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AIDS 2010: Track B (Clinical Science) Highlights

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  1. AIDS 2010: Track B (Clinical Science) Highlights Dr. Andrew Kambugu, Uganda (Lead) Jain Vivek, USA Dr. Gabriel Chamie, USA Dr. Sabrina Kitaka-Bakera, Uganda Dr. Jose Arribas, Spain Dr. N. Kumarasamy, India Dr. Annie Luetkemeyer, USA Dr. Ted Ruel UCSF, USA

  2. Track B Stats

  3. Structure of Report • ART: New Drugs and Novel Treatment Strategies • New ART products • Simplification / Switching • When to Start ART • Co-infections/Co-morbidities • HIV/TB co-infection • HIV/Hepatitis co-infection • HIV and Malignancies • Complications of HIV and ART • Monitoring of ART • Paediatrics

  4. Promising Next-generation INI-ING112276

  5. A Nucleoside-Sparing Strategy- The PROGRESS Study

  6. Treatment Simplification- The SPIRAL Study MOAB0103-SPIRAL SLIDE

  7. Treatment Simplification- The SPARTAN Study

  8. When to Start ART- The CASCADE Collaboration CASCADE-1 AIDS 2010: THLBB201

  9. When to Start ART- The CASCADE Collaboration CASCADE-2 AIDS 2010: THLBB201

  10. When to Start ART- The CHER Trial Analysis (Paeds)

  11. When to Start ART- The CAMELIA Trial (TB)

  12. TB/HIV Co-Infection- The Role of IPT in RLS (MOAB0305) AIDS 2010: MOAB0305

  13. HIV/Hepatitis Co-Infection- Risk of Fractures (TUAB0104) TUAB0104 Slide AIDS 2010: TUAB0104

  14. HIV and Malignancies- Higher Burden in HIV (WEAB0101) AIDS 2010: WEAB0101

  15. HIV and Bone Disease- Association with ART Regimens (WEAB0304) ?WEAB0304- HIV Comps AIDS 2010: WEAB0304

  16. ART Monitoring: VL vs Non VL sites (THAB0102) THAB0102: Monitoring Slide AIDS 2010: THAB0102

  17. Paediatric ART: The PENPACT Study (THLBB104) THLBB104-PENPACT Slide AIDS 2010: THLBB104

  18. What Next After CAPRISA 004?

  19. Key Messages • Newer Drugs may offer simpler, less toxic regimens while maintaining HIV suppression • Nucleoside-sparing regimens (SPARTAN, PROGRESS) • Start ART earlier • Certain: CD4 less than 350, TB, Peads • Less certain: CD4 less than 500 but >350 • TB and ART: Initiate ART at the earliest opportunity • The CAMELIA

  20. Track B Rapporteur Team • Dr. Andrew D Kambugu IDI Uganda • Dr. Jain Vivek, UCSF, USA • Dr. Gabriel Chamie, UCSF, USA • Dr. Sabrina Kitaka-Bakera, Makerere, Uganda • Dr. Jose Arribas, Madrid, Spain • Dr. N. Kumarasamy, Chenai, India • Dr. Annie Luetkemeyer, UCSF, USA • Dr. Ted Ruel UCSF, USA

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