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Overview : Innate Immune Response

Overview : Innate Immune Response. Inflammation. Recruitment from the bloodstream. Inflammation. Phagocytosis of a bacterium. Inflammation. Inflammation. Soluble Molecules. • Proinflammatory cytokines: •IL-1 • TNF a •Antimicrobial peptides

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Overview : Innate Immune Response

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  1. Overview: Innate Immune Response

  2. Inflammation Recruitment from the bloodstream

  3. Inflammation Phagocytosis of a bacterium

  4. Inflammation

  5. Inflammation

  6. Soluble Molecules •Proinflammatorycytokines: •IL-1 •TNFa •Antimicrobial peptides •Acute phase response (APR) and acute phase response proteins •complement proteins •C-reactive protein (CRP) •Mannose-binding lectin (MBL)

  7. Receptors Detect Infection

  8. Receptors Detect Infection •Classification of PRRs: a) signaling b) endocytic •Membrane bound: Toll-like receptors (TLR) C-type lectin receptor (CLR) Scavenger receptors (SRs) Lipopolysaccharide receptor (LPR) •Cytoplasmic: NOD-like receptors (NLR) •Secreted: Mannose-binding lectin (MBL) Complement receptors C-reactive protein (CRP) LPS-binding protein (LBP)

  9. Receptors Detect Infection

  10. Toll-like Receptors

  11. Toll-like Receptors

  12. Cells involved in innate immunity •Neutrophils •Macrophages •Dendritic cells •Natural killer cells

  13. Signal Transduction

  14. Signal Transduction

  15. Signal Transduction

  16. Signal Transduction

  17. Signal Transduction

  18. Ubiquity of Innate Immunity

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