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“Transferrins-R-US”

“Transferrins-R-US”. “An Evolutionary look at the changes in the structure of this protein”. Geoffrey. What’s our Question?. What is the evolutionary relationship among various species using the transferrin protein as a model?

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“Transferrins-R-US”

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  1. “Transferrins-R-US” “An Evolutionary look at the changes in the structure of this protein” Geoffrey

  2. What’s our Question? • What is the evolutionary relationship among various species using the transferrin protein as a model? • How much of the transferrin molecule is conserved in these organisms?

  3. What’s the role of transferrin?

  4. Molecular Phylogenies • Molecular sequencing illuminates the evolutionary history of the molecules themselves and, consequently that of their host organisms.

  5. Organisms Used • Protostome - Arthropoda – Insecta • Apis mellifera (Honey Bee) • Chilo suppressalis (Striped Rice Borer) • Bombyx mori (Silkmoth) • Manduca sexta (Carolina Sphinx) • Galleria mellonia (Greater Wax Moth) • Sarcophaga spp.(Flesh Fly) • Drosophila silvestris (Picture Winged Fly) • Periplaneta americana (Cockroach) • Protoctista • Trypanosoma brucei (African Sleeping Sickness) • Deuterostome -Echinodermata – Echinoidea (Sea Urchins) • Strongylocentrotus purpuratus • Paracentrotus lividus • Tripneustes gratilla • Lytechinus variegatus • Chordata -Mammalia • Homo sapiens bioinformaticus (John Jungck) • Mus musculus (Mouse) • Bufo spp. (Toad) • Oncorhynchus mykiss (Rainbow Trout) • Chordata-Urochordata • Halocynthia roretzi (Sea squirt)

  6. Lord of the Flies

  7. It’s a Bug’s Life!

  8. The “Stars” of the Show

  9. Mastodon-free Zone!

  10. “To chordate or not to chordate?, That is the Question!”

  11. Outsiders? We don’t want no stinkin’ outsiders!

  12. What does this mean? • Cladograms • Deuterostomes separate from protostomes • Similar species cluster together • Does not reflect a pattern in single lobe vs. double lobe molecules

  13. More of what does this mean… • Molecular structure • There are few conserved regions • Not very conserved around functional areas • Only 3 of 8 disulfide bridges and only 1 of 2 hinge strands are conserved

  14. That’s all Folks!

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