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Stem Cells

Stem Cells. Importance of Stem Cell Research. Stem Cell History. 1998 - Researchers first extract stem cells from human embryos 1999 - First Successful human transplant of insulin-making cells from cadavers 2001 - President Bush restricts federal funding for embryonic stem-cell research

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Stem Cells

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  1. Stem Cells

  2. Importance of Stem Cell Research

  3. Stem Cell History 1998 - Researchers first extract stem cells from human embryos 1999 - First Successful human transplant of insulin-making cells from cadavers 2001 - President Bush restricts federal funding for embryonic stem-cell research 2002 - Juvenile Diabetes Research Foundation International creates $20 million fund-raising effort to support stem-cell research 2002 - California ok stem cell research 2004 - Harvard researchers grow stem cells from embryos using private funding 2004 - Ballot measure for $3 Billion bond for stem cells

  4. Stem Cell – Definition A cell that has the ability to continuously divide and differentiate (develop) into various other kind(s) of cells/tissues

  5. Stem Cell Characteristics ‘Blank cells’ (unspecialized) Capable of dividing and renewing themselves for long periods of time (proliferation and renewal) Have the potential to give rise to specialized cell types (differentiation)

  6. Kinds of Stem Cells

  7. Totipotent This cell Can form the Embryo and placenta Pluripotent This cell Can just form the embryo Multi- potent Fully mature

  8. Kinds of Stem Cells • Embryonic stem cells • five to six-day-old embryo • Tabula rasa • Embryonic germ cells • derived from the part of a human embryo or fetus that will ultimately produce eggs or sperm (gametes). • Adult stem cells • undifferentiated cells found among specialized or differentiated cells in a tissue or organ after birth • appear to have a more restricted ability to produce different cell types and to self-renew.

  9. Pluripotent Stem Cells –more potential to become any type of cell

  10. Multipotent stem cells Multipotent stem cells – limited in what the cells can become

  11. Embryonic Stem Cells Mainly from IVF

  12. Sexual Reproduction

  13. Stages of Embryogenesis cleavage 8-cell stage blastocyst Blastocyst inner mass cells

  14. Blastocyst Diagram

  15. Adult Stem Cells An undifferentiated cells found among specialized or differentiated cells in a tissue or organ after birth • Skin • Fat Cells • Bone marrow • Brain • Many other organs & tissues

  16. Induced Pluripotent Stem Cells

  17. Bone Marrow Found in spongy bone where blood cells form Used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. treat patients diagnosed with leukemia, aplastic anemia, and lymphomas Need a greater histological immunocompatibility

  18. Blood Cell Formation

  19. Umbilical cord stem cells Also Known as Wharton’s Jelly Adult stem cells of infant origin Less invasive than bone marrow Greater compatibility Less expensive

  20. Umbilical cord stem cells Three important functions: Plasticity: Potential to change into other cell types like nerve cells Homing: To travel to the site of tissue damage Engraftment: To unite with other tissues

  21. Stem Cell Applications • Tissue repair • - nerve, heart, muscle, organ, skin • Cancers • Autoimmune diseases • - diabetes, rheumatoid arthritis, MS

  22. Tissue Repair • Regenerate spinal cord, heart tissue or any other major tissue in the body.

  23. Replace Skin http://www.youtube.com/watch?feature=player_embedded&v=eXO_ApjKPaI

  24. Heart Disease • Adult bone marrow stem cells injected into the hearts are believed to improve cardiac function in victims of heart failure or heart attack

  25. Leukemia and Cancer • Studies show leukemia patients treated with stem cells emerge free of disease. • Injections of stem cells have also reduces pancreatic cancers in some patients. Proliferation of white cells

  26. Rheumatoid Arthritis • Adult Stem Cells may be helpful in jumpstarting repair of eroded cartilage.

  27. Type I Diabetes • Pancreatic cells do not produce insulin • Embryonic Stems Cells might be trained to become pancreatic islets cells needed to secrete insulin.

  28. Stem cells in the adult brain:

  29. new research – reprogramming cells

  30. Technical Challenges Source - Cell lines may have mutations. Delivery to target areas Prevention of rejection Suppressing tumors

  31. Problems with Adult Stem Cells Mutations can lead to leukemia

  32. Why is Stem Cell Research So Important to All of Us? Stem cells can replace diseased or damaged cells Stem cells allow us to study development and genetics Stem cells can be used to test different substances (drugs and chemicals)

  33. Why the Controversy Over Stem cells? Embryonic Stem cells are derived from extra blastocysts that would otherwise be discarded following IVF. Extracting stem cells destroys the developing blastocyst (embryo). -Questions for Consideration- Is an embryo a person? Is it morally acceptable to use embryos for research? When do we become “human beings?”

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