1 / 20

Influenza Vaccine Responses

Influenza Vaccine Responses. Roland A. Levandowski, M.D. Division of Viral Products. Prepared for Vaccines and Related Biological Products Advisory Committee 18-19 February 2004. Serum Panels for Serologies. 1. ALAN HAMPSON ADULT A/NEW CALEDONIA/20/99-LIKE (H1N1)

garth-guy
Download Presentation

Influenza Vaccine Responses

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Influenza Vaccine Responses Roland A. Levandowski, M.D. Division of Viral Products Prepared for Vaccines and Related Biological Products Advisory Committee 18-19 February 2004

  2. Serum Panels for Serologies • 1. ALAN HAMPSON ADULT A/NEW CALEDONIA/20/99-LIKE (H1N1) • WHO, AUSTRALIA ELDER A/PANAMA/2007/99 (H3N2) • B/SHANGDONG/07/97 • 2. JOHN WOOD, PH.D ADULT A/NEW CALEDONIA/20/99 (H1N1) • NIBSC, ENGLAND ELDER A/PANAMA/2007/99 (H3N2) • B/SHANGDONG/7/97 • 3. TAKATO ODIGARI, PH.D. ADULT A/NEW CALEDONIA/20/99-LIKE (H1N1) • WHO, JAPAN ELDER A/PANAMA/2007/99-LIKE (H3N2) • B/HONG KONG/330/01-LIKE

  3. Serum Panels for Serologies • 4. STEFAN GRAVENSTEIN, M.D. ADULT A/NEW CALEDONIA/20/99 (H1N1) • EASTERN VIRGINIA ELDER A/PANAMA/2007/99 (H3N2) • MEDICAL SCHOOL CHILD B/HONG KONG/1434/2002 • 5. CHRISTINE TURLEY, M.D. CHILD A/NEW CALEDONIA/20/99 (H1N1) • UTMB A/PANAMA/2007/99 (H3N2) • GALVESTON, TEXAS B/HONG KONG/1434/2002 •  6. STEFAN GRAVENSTEIN, M.D. ADULT B/VICTORIA/504/2000 ELDER(VACCINE USED IN 2001-02) • 7. JOHN WOOD, PH.D ADULT B/JOHANNESBURG/5/99 • (VACCINE USED IN 2001-02)

  4. ANTIGENS FOR SEROLOGIES (H1) VACCINE STRAIN A/NEW CALEDONIA/20/99 (H1N1) REPRESENTATIVE CURRENT STRAINS A/DAKAR/85/2003 (H1N1) A/MINNESOTA/18/2003 (H1N1) A/NAGANO/1328/2003 (H1N1) A/BELEM/84066/03 (H1N2) A/ICELAND/123/2003 (H1N2) A/PERU/2223/2003 (H1N2) A/VIRGINIA/20/03 (H1N2)

  5. HI ANTIBODY RESPONSES TO THE H1 COMPONENT2003-2004 INFLUENZA VACCINEADULT POPULATION (CDC)

  6. HI ANTIBODY RESPONSES TO THE H1 COMPONENT2003-2004 INFLUENZA VACCINEELDERLY POPULATION (NIBSC)

  7. HI ANTIBODY RESPONSES TO THE H1 COMPONENT2003-2004 INFLUENZA VACCINEPEDIATRIC POPULATION (CDC AND CBER)

  8. A/NEW CALEDONIA/20/99-LIKE VACCINESSUMMARY TABLEVIRUSES WITH > 50% GMT REDUCTION

  9. ANTIGENS FOR SEROLOGIES (H3) VACCINE STRAIN A/PANAMA/2007/99 REPRESENTATIVE CURRENT STRAINS A/CHILE/82660/2003 A/AICHI/205/2003* A/KUMAMOTO/102/2002* A/FUJIAN/445/2003* A/NAGASAKI/152/2003* * = FUJIAN/411-LIKE A/TEXAS/40/2003* A/TEXAS/141/2003* A/WYOMING/03/2003* A/HONG KONG/1186/2002*

  10. HI ANTIBODY RESPONSES TO THE H3 COMPONENT2003-2004 INFLUENZA VACCINEADULT POPULATION ( AUS )

  11. HI ANTIBODY RESPONSES TO THE H3 COMPONENT2003-2004 INFLUENZA VACCINEELDERLY POPULATION (CDC)

  12. HI ANTIBODY RESPONSES TO THE H3 COMPONENT2003-2004 INFLUENZA VACCINEPEDIATRIC POPULATION (CDC AND CBER)

  13. A/PANAMA/2007/99-LIKE VACCINESSUMMARY TABLEVIRUSES WITH > 50% GMT REDUCTION

  14. ANTIGENS FOR SEROLOGIES (B) VACCINE STRAIN CURRENT VACCINE OLDER VACCINE B/SHANGDONG/7/97+ B/JOHANNESBURG/5/99 B/HONG KONG/1434/2002+ B/VICTORIA/504/2000 REPRESENTATIVE CURRENT STRAINS B/SICHUAN/259/2003+ B/BADEN-WURTENBURG/26/2002* B/SHAHGHAI/361/2002* B/JIANGSU/10/2003* + = HONG KONG/330-LIKE B/JILIN/20/2003* * = SHANGHAI/361-LIKE B/MALAYSIA/879/2003* B/WASHINGTON/3/2003*

  15. HI ANTIBODY RESPONSES TO THE B COMPONENT2003-2004 INFLUENZA VACCINEADULT POPULATION (NIBSC)

  16. HI ANTIBODY RESPONSES TO THE B COMPONENT2003-2004 INFLUENZA VACCINEELDERLY POPULATION (CDC)

  17. HI ANTIBODY RESPONSES TO THE B COMPONENT2003-2004 INFLUENZA VACCINEPEDIATRIC POPULATION (CDC AND CBER)

  18. HI ANTIBODY RESPONSES TO THE B COMPONENT2001-2002 INFLUENZA VACCINEADULT AND ELDERLY (NIBSC AND CBER)

  19. B/HONG KONG/330/2001-LIKE VACCINESSUMMARY TABLEVIRUSES WITH > 50% GMT REDUCTION

  20. Influenza Vaccine ResponsesSummary Studies with sera collected after immunization with current vaccines show that: • Representative influenza A (H1N1) and (H1N2) viruses are well-inhibited • Many a/Fujian/411/2002 (H3N2)-like viruses are less well inhibited than the the vaccine strain • B/Hong Kong/330/2001-like viruses are well inhibited but B/Shanghai/361/2002 and similar viruses are less well inhibited than the vaccine strains

More Related