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Niacin (Nicotinic Acid)

Niacin (Nicotinic Acid). C 6 H 5 NO 2. Nicotinamide - no reduction in blood cholesterol Inositol Hexaniacinate - not much research, unlikely that it lowers cholesterol. "flush free" Nicotinic Acid - shown to have an effect on blood cholesterol Mechanism of action

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Niacin (Nicotinic Acid)

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  1. Niacin (Nicotinic Acid) C6H5NO2

  2. Nicotinamide- no reduction in blood cholesterol Inositol Hexaniacinate- not much research, unlikely that it lowers cholesterol. "flush free" Nicotinic Acid- shown to have an effect on blood cholesterol Mechanism of action • Inhibits free fatty acid release from adipose tissue through inhibition of cyclic AMP accumulation. • Decreases the rate of liver synthesis of LDL and VLDL. http://purebulk.com/niacin-usp-powder.html http://www.worldofmolecules.com/supplements/niacin.htm

  3. Typical Usage • 1 g/day or more of niacin can decrease CVD biomarkers. • Combining nicotinic acid with Statin intake has been shown to be helpful in lowering cholesterol http://www.eatingwell.com/nutrition_health/nutrient_library/niacin

  4. Safety • "Extended release" tablets = decreased flushing, butmore risk of liver toxicity. Especially avoid "slow release" • Combining niacin & statin intake increases the risk of liver enzyme elevation. • SOP: since regular labs are needed, doctor supervision is necessary for niacin in amounts above the UL. http://www.physicianformulas.com/store/Scripts/prodView.asp?idproduct=199 http://www.directlyfitness.com/2011/niacin-supplements/

  5. Coenzyme Q10

  6. Mechanism of action Key player in the electron transport chain • Promotion of ATP synthesis • Prevention of oxidative damage http://www.answerbag.com/q_view/1808988 Lipid soluble antioxidant in the cell membrane (http://people.csail.mit.edu/seneff/statins_muscle_damage_heart_failure)

  7. Manufacture Fermentation, using bacteria or yeast is the least expensive way to produce coQ10 The fermented process yields an all trans form of coQ10 which is the same form found in the body. http://www.kanekaq10.com/

  8. Efficacy & Dosage • People with the largest deficiency of CoQ10 seem to derive the greatest benefit from supplemental CoQ10. As people age or smoke, their cellular levels of CoQ10 go down. • Hypertension: 100-200 mg/day • Angina: 150 mg/day • To reduce risk of 2nd MI: 120 mg/day http://www.dailytravelphotos.com/archive/2010/10/18/

  9. Safety • Generally safe, however daily usage of greater than 300 mg/day for long periods may cause elevated liver enzymes. • Contraindicated for use with anticoagulants. • Patients with liver disease should not use coQ10. • In less than 1% of patients, GI distress, appetite suppression, heartburn and allergic rash have been reported

  10. Availability & Cost • Prices range from $5- $170 • Least expensive option is to buy Coq10 on its own, but must take with lipids • A good compromise between cost and absorption is a soft gel with the product suspended in some type of oil. • Highest cost/ best absorption : "enhanced solubility" bodykind.com

  11. Overall impression • Generally recognized as safe • May boost energy on a cellular level • Slightly high cost, but enhanced solubility option might be worth it. • This supplement receives arating because its efficacy has been proven and it is fairly safe to take.

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