1 / 12

The role of information technologies in the automation of DNA sequencing (1980-1992)

The role of information technologies in the automation of DNA sequencing (1980-1992). Miguel García-Sancho Centre for the History of Science Imperial College, London Miguel.garcia-sancho03@imperial.ac.uk. Science always implies personal involvement

gavivi
Download Presentation

The role of information technologies in the automation of DNA sequencing (1980-1992)

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. The role of information technologies in the automation of DNA sequencing (1980-1992) Miguel García-Sancho Centre for the History of Science Imperial College, London Miguel.garcia-sancho03@imperial.ac.uk

  2. Sciencealways implies personal involvement Technologies are protocols handled by researchers Scientific processesmay be automated Technologiesare autonomous apparatus

  3. John Sulston (LMB, Cambridge) Michael Hunkapiller (Caltech-Applied Biosystems)

  4. The autoradiograph world Inelegant -Spots could not be automatically processed by a computer -Computer, unlike eye, could not correct the positions of the spots

  5. Autoradiograms vs. colour strings

  6. “Do not be confused! The Model 370A DNA Sequencer (…) should NOT be thought of in terms of the standard sequencing gel or gel reader. With the 370A, the bands (…) are detected with a laser within a single (…) horizontal plane on the gel, AS THEY PASS THAT POINT. The information is stored by computer. At the end of the run, the data collected will be displayed on the screen and analysed. Note that it is not necessary (…) to be concerned about the separation of all the bands after a certain period of time. It is not necessary to save the gel as a ‘picture’ of your sequence information” 1986

  7. Peak view vs. gel view

  8. Adoption HP’s strategies

  9. -Garcia-Sancho, M. (2007) “The rise and fall of the idea of genetic information (1948-2006)” in Genomics, Society and Policy, 2(3), www.gspjournal.com -Garcia-Sancho, M. (2007) “Mapping and sequencing information: the social context for the genomics revolution” in Endeavour, 31(1), http://dx.doi.org/10.1016/j.endeavour.2007.01.006

More Related