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Circulación Cerebral y Demencia Senil

Circulación Cerebral y Demencia Senil. Interactions between VaD and AD. VaD. VaD+AD. Pure AD. “ mixed ”. Pure VaD. infarcts, white matter lesions (WMLs) vascular risk factors. post-stroke dementia. Source: G Roman San Antonio TX.

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Circulación Cerebral y Demencia Senil

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  1. Circulación Cerebral y DemenciaSenil

  2. Interactions between VaD and AD VaD VaD+AD Pure AD “mixed” Pure VaD infarcts, white matter lesions (WMLs) vascular risk factors post-stroke dementia Source: G Roman San Antonio TX

  3. Iason Pratensis(Jason de Pratis) published in Basle (1549) the first textbook of neurology De Cerebri Morbis It included a chapter on dementia De memoriae detrimento Pestronk A.The first neurology book. De Cerebri Morbis...(1549) by Jason Pratensis. Arch Neurol 1988 Mar;45(3):341-4.

  4. Thomas Willisat age 45 (1667) 1st description of post-apoplectic dementia: “Dullness of mind and forgetfulness and then afterwards …a stupidity and foolishness. In many, stupidity has accompanied the palsie or has gone before apoplexy” De Anima Brutorum 1672 In Willis' time, the word foolishness (stultitia in Latin, from stultus foolish, meaning "to be of unsound mind") was equivalent to dementia

  5. A BRIEF HISTORY OF DEMENTIA KraepelinArteriosclerotic Dementia Senile & Presenile AD DEMENTIA DSM IV-Executive Dysfunction Th. WillisDementiaPost-apoplexy VCD VCI ErkinjunttiCortical vs. Subcortical DSM-I Chronic Brain Syndrome CADASIL 1st genetic form of VaD Roman NINDS-AIREN Criteria Binswanger, Alzheimer Vascular Dementia Roman Vascular Dementia HachinskiScale DSM-IIIMID 2012 1672 1894 1907 1952 1974 1976 1980 1984 1985 1987 1993 1994 1996 Katzman: AD is the Main Cause of Atrophy and Dementia NINDS-ADRDA Criteria for AD VaD VaD Pathological reports of Alzheimer’s disease AD

  6. Coronary circulation Cerebral circulation Source: S Salloway

  7. LOUIS PASTEUR (1822-1895) 1854-57 Professor of Chemistry, Lille 1857-67 Director École Normale Supérieure, Paris 1865-70 Silkworm diseases 19 Oct 1868 First stroke, L hemiplegia (Age 46) Pasteur at his laboratory working on the rabies vaccine (portrait by Edelfelt).

  8. Pasteur: Left hemiparesis

  9. LOUIS PASTEUR (1822-1895) 1854-1857 Professor of Chemistry, Lille 1857-1867 École Normale Supérieure, Paris 1865-1870 Silkworm diseases 19 Oct 1868 First stroke, L hemiplegia (Age 46) 1871-1876 Studies on fermentation and beer 1877-1880 Anthrax, fowl cholera 1881-1895 Rabies vaccine Oct 1887 2nd stroke (Age 65) 1894 3rd stroke (Age 72)

  10. “Common Sense” Reisch Margarita Philosophica (1513)

  11. Snowdon D, et al. JAMA March 12, 1997; 277(10): 813-817

  12. Concept-changing factors • Progress in the neurosciences • Neuroimaging • Neuropathology • Cerebral Blood Flow • Neuropsychology Frontal Lobe • Genetics • Epidemiology • Pharmacology

  13. special article Vascular dementia: Diagnostic criteria for research studies Report of the NINDS-AIREN International Workshop GC Román, TK Tatemichi, T Erkinjuntti, JL Cummings, J Masdeu, JHGarcía, L Amaducci, J-M Orgogozo, A Brun, A Hofman, DM Moody, MD O’Brien, T Yamaguchi, J Grafman, BP Drayer, DA Bennett, M Fisher, J Ogata, E Kokmen, F Bermejo, PA Wolf, PB Gorelick, KL Bick, AK Pajeau, MA Bell, C DeCarli, A Culebras, AD Korczyn, J Bogousslavsky, A Hartmann, and P Scheinberg NEUROLOGY 1993;43:250-260

  14. NINDS-AIREN International Workshop on Vascular Dementia; April 19-21, 1991; NIH Campus, Bethesda, Md NINDS/CSN Workshop Bethesda 2005

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