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Discover how vital elements like carbon, oxygen, hydrogen, and nitrogen bond to form key molecules in living organisms. Learn about carbohydrates, fats, proteins, and nucleic acids, and how we utilize them for growth, repair, and energy production. Dive into the world of macromolecules like lipids and carbohydrates, and explore the role of water in sustaining life. Uncover the processes of synthesis and digestion that drive the creation and breakdown of vital molecules in our bodies. From the building blocks of amino acids to the structure of DNA, biochemistry offers a fascinating glimpse into the intricate chemistry that powers life.
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Biochemistry What does CHEMISTRY have to do with each of these BIOLOGICAL PROCESSES? www.vaguebuttrue.com upload.wikimedia.org news.nationalgeographic.com stuffeducatedlatinoslike.files.wordpress.com www.insomniacslounge.com find-happiness.com
Biochemistry Elements of Life • 96% of living organisms are made of: • carbon (C) • oxygen (O) • hydrogen (H) • nitrogen (N)
Molecules of Life • Put C, H, O, Ntogether in different ways to build living organisms • What are bodies made of? • carbohydrates • sugars & starches • fats (lipids) • proteins • nucleic acids • DNA, RNA
Why do we eat? • We eat to take in more of these chemicals • Food for building materials • to make more of us (cells) • for growth • for repair • Food to make energy • calories • to make ATP ATP
Don’t forget water • Water • 65% of your body is H2O • water is inorganic • doesn’t contain carbon • Rest of you is made of carbonmolecules • organicmolecules • carbohydrates • proteins • fats • nucleic acids
Building large molecules of life • Chain together smaller molecules • building block molecules = monomers (“mono”=one) • Big molecules built from little molecules • Polymers (“poly”=many
amino acid amino acid amino acid amino acid amino acid amino acid – – – – – Building important polymers Carbohydrates= built from sugars sugar – sugar – sugar – sugar – sugar – sugar Proteins= built from amino acids Nucleic acids (DNA) = built from nucleotides nucleotide – nucleotide – nucleotide – nucleotide
amino acid amino acid amino acid amino acid amino acid amino acid – – – – – Building important polymers Carbohydrates= built from sugars sugar – sugar – sugar – sugar – sugar – sugar Proteins= built from amino acids Nucleic acids (DNA) = built from nucleotides nucleotide – nucleotide – nucleotide – nucleotide
How to build large molecules • Synthesis • building bigger molecules from smaller molecules • building cells & bodies • repair • growth • reproduction ATP +
How to break large molecules • Digestion • taking big molecules apart • getting raw materials • for synthesis & growth • making energy (ATP) • for synthesis, growth & everyday functions ATP +
Example of digestion STARCH/GLYCOGEN ARE DIGESTED TO GLUCOSE ATP ATP ATP ATP ATP ATP Starch(glucose storage in plants) glucose Glycogen(glucose storage in animals) ATP
Example of synthesis amino acids = building block protein = polymer protein amino acids • Proteins are synthesized by bonding amino acids
Four classes of Organic Molecules aka Macromolecules • Carbohydrates 2.Lipids • Proteins 4.Nucleic Acids
Macromolecule: Carbohydrate • Carbohydrate (Starch/Sugar) -Elements: C, H, O (1:2:1 ratio) -Shape: Hexagon Glucose Another name for Glucose is SUGAR FYI: Saccharide means SUGAR -Function: Quick source of ENERGY; structure (cell wall in plants made of cellulose) -Monomer“subunit”: Monosaccharide -Names end in –ose Examples: Fructose, Sucrose, Cellulose
Macromolecule: Carbohydrate -Examples of Carbohydrate: • 1. Monosaccharide“One Sugar”: a) glucose made by plants • 2. Disaccharide“Two Sugars”: a) table sugar (Sucrose) • 3. Polysaccharide“Many Sugars”: a) starch- stores energy in plants (potatoes) b) cellulose- makes up plant cell walls c) chitin- exoskeleton of arthropods d) glycogen- stored in animal liver
Polysaccharides Glycogen in animal liver Starch in Potato Cellulose in plant cell walls Chitin in exoskeleton
Cellulose • Cell walls in plants • herbivores can digest cellulose well • most carnivores cannot digest cellulose • that’s why they eat meatto get their energy & nutrients • cellulose = roughage • stays undigested • keeps material moving in your intestines
Helpful bacteria • How can cows digest cellulose so well? • BACTERIA live in their stomachs & help digest cellulose-rich (grass) meals
Macromolecule: Lipid 2.Lipid(Fat) -Elements: C, H, O -Shape: Letter E -Function: a) long term ENERGY storage b) insulation (think about whale blubber) c) makes up cell membranes d) cushions organs -Monomer“subunit”: Fatty Acids -Examples: Oils (potatoes chips), Fats, Waxes, Steroids & Phospholipids Glycerol (backbone) 3 Fatty acids
Molecular Structure of FatNot a chain/polymer= just a “big fat molecule” Fatty acid Glycerol
1) Saturated: -SOLID at room temperature -No Double Bonds -“Bad Fats” - Limit the amount in diet Examples: Cheese and butter 2) Unsaturated: -LIQUID at room temperature -Has Double Bonds -”Good Fats” - Better choice for diet Examples: plant, vegetable, and fish fats Two Types ofLipids:
Other lipids in biology • Cholesterol • good molecule in cell membranes • make hormones from it • including sex hormones • but too much cholesterol in blood may lead to heart disease www.offthemarkcartoons.com
Other lipids in biology • Cell membranes are made out of lipids • phospholipids • heads are on the outside touching water • “like” water • tails are on inside away from water • “scared” of water • forms a barrier between the cell & the outside
Multipurpose molecules Proteins: greatmusclebuildingworkouts.info
Examples of Proteins: • muscle • skin, hair, fingernails, claws • collagen, keratin • pepsin • digestive enzyme in stomach • Insulin • Hormone that controls blood sugar levels • Hemoglobin • Oxygen-carrying part of blood cells gomuscles.net www.bottlebooks.com listsoplenty.com
Macromolecule: Protein 3. Protein(Polypeptides) -Elements: C, H, O, N -Shape: -Function: a) Speed up chemical reactions (Enzymes) b) Transport molecules in the cell membrane c) Movement, regulation, and structure -Monomer“subunit”: Amino Acids (Amino Acids are held together by a peptide bond) Amino Acid Group Peptide Bond Amino Acids
Macromolecule: Protein -Names end in “-in” or “-ase” Examples: Keratin, Actin, Hemoglobin, Insulin, Protease orLipase -Examples of Proteins 1) Hemoglobin: transports oxygen in red blood cells 2) Insulin: regulates blood sugar levels 3) Keratin: waterproofs skin and nails 4) Actin: contraction in muscle cells 5) Transport Proteins: helps move molecules across cell membranes 6) Protease: helps break down proteins 7) Lipase: breaks down lipids
H | —C— | H amino acid amino acid amino acid amino acid amino acid – – – – C—OH —N— O H || Proteins amino acids • Building block = 20 different amino acids There are20 of us… like 20 differentletters in analphabet…Can make lots of differentwords variable group
collagen 3-D protein structure • Proteins fold & twist into 3-D shapes • that’s what happens in the cell! • Different shapes = different jobs growthhormone hemoglobin pepsin
With Proteins…Its shape that matters! • Proteins do their jobs, because of their shape • Unfolding a protein destroys its shape • wrong shape = can’t do its job • unfolding proteins = “denature” • temperature • pH (acidity) unfolded“denatured” folded
Macromolecules and Indicators • Carbohydrates – • Sugar - Benedicts Solution • Solution will turn from blue to red-brown. • Starch – Iodine (IKI) • Solution will turn from yellow to black. • Lipids – Brown Paper Test • Paper will have a “greasy” spot. • Proteins – Biuret Test • Solution will turn violet. Lab: Indicators
Macromolecule: Nucleic Acid 4. Nucleic Acid -Elements: C,H,O,P,N -Shape: -Function: stores/transfers genetic information directions for making proteins (protein synthesis------DNA>RNA>Protein) -Monomer“subunit”: Nucleotides -Examples: 1) DNA (Deoxyribonucleic Acid) 2) RNA (Ribonucleic Acid) Phosphate Nitrogen Base Sugar Rectangle Circle Pentagon
Macromolecule: Nucleic Acid DNA:A,T,G,C RNA: A, U, G, C DNA: Deoxyribose Sugar RNA: Ribose Sugar
5 O 3 3 O P P 5 5 C O G 1 3 2 4 4 2 1 3 5 O P P T A 3 5 O O 5 P P 3 Nucleotide: DNA “Double Helix”
C A G T A C T G Weak Hydrogen bonds Why do we need weak bonds between the base pairs? strong bonds 30.media.tumblr.com Structure of DNA 1:14 http://www.dnatube.com/group/dna_structure/?viewkey=a1a4f25f62e0eb5261ca&search_id=structure