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Understanding Aging, Cancer, and Environmental Factors

Explore the intricate relationship between aging, cancer, gene loss, DNA repair, proteasome function, telomere maintenance, and environmental stress factors. Learn about the impact of oxidative damage, proteasomal degradation, gene expression regulation, and reversing the cellular "Garbage Catastrophe" in the context of aging and anti-aging strategies. Delve into the influence of environmental factors like nutrition, excess calories, obesity, smoking, alcohol consumption, occupational hazards, radiation, and other carcinogenic agents in cancer development. Understand the differences between normal and cancer cells in terms of proliferation, energy requirements, and response to environmental stresses through genetic and cellular mechanisms.

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Understanding Aging, Cancer, and Environmental Factors

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  1. AGING & CANCER

  2. Gene loss DNA Repair Proteasome telomare STOP CYCLE/AGING ENVIRONMENTAL STRESS mutation silencing and expressing gene CANCER

  3. Aging as a catabolic malfunctionand “Garbage Catastrophe” Young and clean Old and Dirty Oxidative damage Oxidative damage Proteosomal degradation Proteosomal degradation “Garbage catastrophe” Oxidized and cross-linked proteins (Lipofuscin)‏ Oxidized and cross-linked proteins Anti-aging Reversing the catastrophe

  4. Gene loss DNA Repair Proteasome telomare STOP CYCLE/AGING ENVIRONMENTAL STRESS mutation silencing and expressing gene CANCER

  5. ENVIRONMENTAL FACTOR • Nutrition excess calories cancers of colon, rectum, stomach, breast, ovaries • excess fat consumtion • obesity • cigaretes 1/3 of cancer deaths Cancers of lung, pancreas, mouth, larynx, liver, • alchohol esophagus and bladder • occupation 5% of cancerdeaths cancers of lung, bladder, stomach, blood, liver, • bones, skin • Radiation 3% /xray, uv, isotop blood and skin • Other drug, virus, bacteri various

  6. Normal and Cancer cells contrast in their proliferation capacity Vs Normal cells Cancer cells Unlimited number of divisions Limited number of divisions Permanent growth arrest/senescence Tumor

  7. CANCER NEED MORE ENERGY

  8. environmental stress healty nutrient/suplement HSF, HO-1, NOS, P45OR (GENE PROTECTOR)‏ p53, HSF necrotic repair mechanism, protecting cell Apoptosis Cancer interaction of genes between stressor and food cause cancer

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