Lydia MAIGNE, PhD Laboratoire de Physique Corpusculaire maigne@clermont2p3.fr

1. Grid based telemedicine application for GATE Monte Carlo dosimetric studies using HOPE (Hospital Platform for E-health) Lydia MAIGNE, PhD Laboratoire de Physique Corpusculaire maigne@clermont.in2p3.fr Credits: M.Diarena, S.Nowak, C. Thiam, D.Donnarieix and V.Breton

2. Better treatment requires better planning • Today: analytic calculation to compute dose distributions in the tumor or to model scans • For new Intensity Modulated Radiotherapy treatments, analytic calculations off by 10 to 20% near heterogeneities • Quantification of the radioactivity inside an organ or a tumor after an internal dosimetry treatment very difficult to perform • Better alternative: Monte Carlo (MC) simulations unacceptable time consuming • The GRID impact: reduce MC computing time to a level acceptable by the physician Lydia Maigne EGEE User Forum – Clermont-Ferrand - 11-14 February 2008

3. GATE: Geant4 Application for Tomographic Emission Développements dédiés SPECT/TEP • Goal: Develop a platform dedicated to PET and SPECT applications • Based on Geant4 GATE • Dedicated tools for imaging noyau GEANT4 • Easy to use • Ensure a long terme development • Shared developement • OpenGATE collaboration Lydia Maigne EGEE User Forum – Clermont-Ferrand - 11-14 February 2008

4. PET camera Ocular brachytherapy treatment Radiotherapy Some examples of medical physics applications: Medical physics Application OpenGATE collaboration http://www.opengatecollaboration.org Lydia Maigne EGEE User Forum – Clermont-Ferrand - 11-14 February 2008

5. Random numbers consumption depends of: interactions, number of particles générated, etc… • Linear RN consumption in function of the number of particles generated Status 1 Status 2 Status 3 status000.rndm status001.rndm status002.rndm Pseudorandom number sequences x1 x2 x3 x4 x5 x6 x7 x8 x9 x10 x11 x12 x13 x14 x15 • 1000 status of the Random Number Generator with a length of 3.1010 numbers. Lydia Maigne EGEE User Forum – Clermont-Ferrand - 11-14 February 2008

6. 6°) Split the simulations: • A GATE simulation generating a lot of particles in matter could take a very long time to run on a single processor • So, the big simulation generating 10M of particles is divided into little ones, for example • 10 simulations generating 1M of particles • 20 simulations generating 500000 particles • 50 simulations generating 200000 particles …… • All the other files needed to launch Monte Carlo simulations are automatically created with the program. jdl files jobXXX.jdl Status files statusXXX.rndm Script files scriptXXX.csh Macro files macroXXX.mac Required files Lydia Maigne EGEE User Forum – Clermont-Ferrand - 11-14 February 2008

7. 1°) Obtain scanner slices images The head is imaged using a MRI and/or CT scanner An ocular brachytherapy treatment 2°) Treatment planning 3°) Ocular brachytherapy treatment Calculation of deposit dose on the tumor (~1mn): A treatment plan is developed using the images Irradiation of the ocular tumor using an ophthalmic applicator Lydia Maigne EGEE User Forum – Clermont-Ferrand - 11-14 February 2008

8. HOPE portal Lydia Maigne EGEE User Forum – Clermont-Ferrand - 11-14 February 2008

9. How it works on the grid • The telemedicine infrastructure allows users to exchange medical data from different hospitals. • The information exchange takes place between web services deployed in different locations and is completely transparent to end users. • Information are transferred between different locations only on request using SOAP messages over an SSL secured channel. Security: Lydia Maigne EGEE User Forum – Clermont-Ferrand - 11-14 February 2008

10. 1°) The connexion: to a smart adaptive identifier • Patient smart card • The card will host an identifier based on hash value of name, birth and family components • Each medical act is stored as a small string in the card • Encryption • Between the PACS server and the web portal, patient ID and medical act will be a part of a key used to encrypt images to secure transactions • Data retrieval system • A secure authentication for patients to retrieve their personal data • Physician authentication • Healthcare professional smart card + Password Look at the poster of Paul de Vlieger: Smart adaptive identifier for a medical data retrievement system Lydia Maigne EGEE User Forum – Clermont-Ferrand - 11-14 February 2008

11. 1°) Enter a new patient: patient sheet Lydia Maigne EGEE User Forum – Clermont-Ferrand - 11-14 February 2008

12. 2°) Obtain the medical images of the tumor from the PACS system • Scanner slices of the patient brain in DICOM or DICOMRT format Scanner slices: DICOM or DICOMRT format • Size of the scan slices: • 512 X 512 X 1 pixels • Size of a voxel in the image: • 0,625 X 0,625 X 1,25 mm Lydia Maigne EGEE User Forum – Clermont-Ferrand - 11-14 February 2008

13. 2°) Obtain the medical images of the tumor from the PACS system Lydia Maigne EGEE User Forum – Clermont-Ferrand - 11-14 February 2008

14. Replicate image on the other SEs Copy image.raw on a SE Storage Element Storage Element Storage Element Storage Element DICOM Viewer Computing Element Computing Element Computing Element Computing Element 3°) Register and replicate the binary image on SEs: Site 1 Scanner slices: DICOM format Site 2 User interface Concatenation Site 3 Anonymisation Image: text file Site 4 Binary file: Image.raw Size 19M Lydia Maigne EGEE User Forum – Clermont-Ferrand - 11-14 February 2008

15. Storage Element Storage Element Storage Element Storage Element Computing Element Computing Element Computing Element Computing Element 4°) Register the confidential data: Site1 Register lfn in the database Query a lfn to the database Scanner slices: DICOM format Site2 User interface Concatenation Site3 Anonymisation AMGA Database Image: text file Site4 Binary file: Image.raw Size 19M Lydia Maigne EGEE User Forum – Clermont-Ferrand - 11-14 February 2008

16. GATE Copy the medical image from the SE to the CE Submission of jdls to the CEs Retrieving of root output files from CEs GATE GATE Storage Element Storage Element Storage Element Storage Element GATE Computing Element Computing Element Computing Element Computing Element 5°) Submission on the Grid: Site1 Site2 Scanner slices: DICOM format User interface Site3 Concatenation Anonymisation AMGA Database Image: text file Site4 Binary file: Image.raw Size 19M Lydia Maigne EGEE User Forum – Clermont-Ferrand - 11-14 February 2008

17. 5°) Submission on the Grid: Lydia Maigne EGEE User Forum – Clermont-Ferrand - 11-14 February 2008

18. 6°) Results: Treatment plans Lydia Maigne EGEE User Forum – Clermont-Ferrand - 11-14 February 2008

19. Computing time tests Lydia Maigne EGEE User Forum – Clermont-Ferrand - 11-14 February 2008

20. Conclusion and perspectives • New convivial web platforms for different biomedical applications • Tools begin to be used by medical staff • Grid stability, EGEEIII infrastructure • Develop convivial end users tools to be used in hospital • Federate the communities (the HealthGrid association) • Confidential data, legal issues • Think about the electronic medical patient file and how the grid could deal with in a near future. Lydia Maigne EGEE User Forum – Clermont-Ferrand - 11-14 February 2008

21. References • EGEEII biomedical applications: • http://egee-na4.ct.infn.it/biomed/egee2-applications.html • WISDOM: • www.wisdom.healthgrid.org • LifeGrid project: • www.lifegrid.org • GATE Monte Carlo platform: • www.opengatecollaboration.org • HealthGrid initiative: • www.healthgrid.org • Contacts: • PCSV team web site: http://clrwww.in2p3.fr/PCSV • Lydia Maigne: maigne@clermont.in2p3.fr Lydia Maigne EGEE User Forum – Clermont-Ferrand - 11-14 February 2008