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Single dose for rabies pre-immunization. P. Khawplod 1 , H. Wilde 2 ,T. Kamolthum 3 ,Visith Sitprija 1 . 1Queen Saovabha Memorial Institute, The Thai Red Cross Society, Bangkok, Thailand. 2 Faculty of Medicine , Chulalongkorn University , Bangkok , Thailand.
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Single dose for rabies pre-immunization P. Khawplod1 , H. Wilde2 ,T. Kamolthum3 ,Visith Sitprija1. 1Queen Saovabha Memorial Institute, The Thai Red Cross Society, Bangkok, Thailand. 2 Faculty of Medicine , Chulalongkorn University , Bangkok , Thailand. 3 Provincial Public Health Office of Pitsanulok , Thailand.
The Ab response in incomplete PET cases(1 - 3 injections) All subjects received TRC-ID 2-2-2-0-1-1 (PVRV lot.no. L1012, potency 8.7 IU/0.5mL)
Pre-exposure vaccination Shorten time & reduce cost
Objective : To evaluate the immune memory of two abbreviated pre-exposure rabies vaccinationschedules
Study 1 • One week schedule ( 3 injections on day 0,3,7) Study 2 • One clinic visit (Single dose)
One week schedule Gr.A ID (2 sites) on day 0, 7 ,28 Gr.B ID (2 sites) on day 0, 3, 7 Gr.C IM on day 0, 3, 7 PVRV potency 7.5 IU/0.5 mL
One week schedule Booster : ID (2 sites) on day 0,3 1 year later Blood collection : before booster (1 year) , 7 and 14 days PVRV potency 7.5 IU/0.5 mL
Conclusions: • 3 injections on day 0,3,7 is as immunogenic as 3 injections on day 0,7,28 • Provide at least 1 year of immune memory
Pre-immunization ID 0.1 ml (2 sites) on day 0 Single dose for rabies pre-immunization Booster ( 1 year later ) ID 0.1 ml ( 2 sites ) on day 0, 3 PVRV lot no 0525 potency 7.5 IU/0.5mL
Single dose rabies pre-immunization Single dose injection
Conclusion: • One clinic visit ( ID 0.1 ml (2 sites) one time) provide at least 1 year of immune memory
Pre-immunization vaccination ID 0.1 ml (1 site) on day 0 Single dose for rabies pre-immunizationin Petchaboonprovince • Booster ( 1 or 3 years later ) ID 0.1 ml ( 1 site ) on day 0, 3 PCEC Lot no725potency 7.25 IU/mL
Conclusions: • 3 injections on day 0,3 and 7 • One clinic visit • ID 0.1 ml ( 2 sites) one time Provide immune memory at least 1 year or more
Application for rabies pre-immunization • reliable booster vaccination • long lasting • ???? NEED FURTHER STUDIES
Preventions Animal control Bite Prevention PET = 100% Pre-exposure vaccination Exposed