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Lecture 25: DNA repair, recombination; changes in chromosome number

Lecture 25: DNA repair, recombination; changes in chromosome number. Non-homologous end joining repairs DSBs. DSB repair by homologous recombination. Sister chromatids. Initiation of meiotic recombination. Recombination: Holliday junctions. Holliday junction. Gene conversion.

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Lecture 25: DNA repair, recombination; changes in chromosome number

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  1. Lecture 25: DNA repair, recombination; changes in chromosome number

  2. Non-homologous end joining repairs DSBs

  3. DSB repair by homologous recombination Sister chromatids

  4. Initiation of meiotic recombination

  5. Recombination: Holliday junctions Holliday junction

  6. Gene conversion

  7. Gene conversion mechanism

  8. Gene conversion vs. crossover

  9. Chromosome ploidy

  10. Monosomy and trisomy are caused by nondisjunction

  11. Turner syndrome (45, X)

  12. Klinefelter syndrome (47, XXY)

  13. Down syndrome (47, 21+)

  14. Maternal age effect in Down syndrome

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