Medical Devices Group

1. Bone Morphogenic Proteins in Spine Fusion MarketBiotech Meets Orthopedics in Latest Spine Procedure Technology “Spine implants is the fastest growing segment in the $7-billion U.S. orthopedic implants market, and bone morphogenic proteins (BMP) have the potential to increase success rates among the 300,000 plus spine fusions that take place each year in the country.” Medical Devices Group

2. Industry Trends • BMP patents owned by Stryker and Wyeth will discourage new entrants to the U.S. market • Tough regulatory environment will slow entrance of new products to • market • Medtronic InFUSE will have virtual monopoly of the spine BMP market till 2007. Other products are yet to undergo clinical trials • Although BMPs are effective, surgeons are thinking twice due to cost

3. Industry Trends (Cont’d) • Insurance companies are not convinced about BMPs’ cost/benefit ratio • BMPs are now restricted to only one cumbersome surgical approach in spine fusion by FDA due to safety issues. Addressing these issues can widen the application of BMPs several fold. • Widening the indication of BMPs to other parts of the spine can increase frequency of use • Markets outside the U.S. may not be receptive to BMP at current prices

4. Key Features • Frost & Sullivan Provides: • Detailed insights into recent developments and trends • Drivers, restraints, challenges, and strategic recommendations • Analyst insights on emerging technologies • Market forecasts and opportunity analysis • Growth opportunities and emerging applications • SWOT analysis for companies and technologies

5. What We Offer • Coverage: The United States, Asia • Proven methodology encompassing extensive primary and secondary data and research • Focused information and strategies that cover business and technology issues • Credible data and analysis highlighting industry dynamics • Winning strategies to help you create precise business plans

6. Who Will Benefit? Current Market Participants • Find out how you compare with the competition • Assess current and future drivers and restraints • Determine and exploit new market share opportunities New Entrants • Analyze challenges associated with the industry • Calculate time scales for strategy implementation • Position yourself to capitalize on the market’s unmet needs Investment Community • Analyze long-term strategies of market participants • Determine which participants will outperform the competition • Assess attractiveness of investing in the medical devices market

7. What’s Included • Drivers, restraints, and trends • Top companies • Strategic recommendations • Forecasts • Surgeon opinions • Feedback from healthcare organizations • Assessing price sensitivity

8. Key Market Participants • Manufacturers & Biotech Co. • Curis, Inc. • DePuy Spine, Johnson & Johnson • Medtronic Sofamor Danek • Orthologic • Stryker Corp. • Healthcare Organizations • Aetna • Anthem • Blue Cross Blue Shield of Illinois • Empire Blue Cross Blue Shield • Kaiser Permanente • WellPoint • End Users and Specialists • Scientific Researchers with expertise in BMP • Spine surgeons in U.S. & Asia

9. For More Information • Call toll free 877 GO FROST (877.463.7876) • Fax toll free 888.690.3329 • Email myfrost@frost.com • Visit www.frost.com